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3zq6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3zq6 is ON HOLD Authors: Sherrill, J., Mariappan, M., Dominik, P., Hegde, R.S., Keenan, R.J. Description: ADP-ALF4 COMPLEX OF M. THERM. TRC40) |
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| - | '''Unreleased structure''' | ||
| - | + | ==ADP-ALF4 COMPLEX OF M. THERM. TRC40== | |
| + | <StructureSection load='3zq6' size='340' side='right'caption='[[3zq6]], [[Resolution|resolution]] 2.11Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3zq6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZQ6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.107Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zq6 OCA], [https://pdbe.org/3zq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zq6 RCSB], [https://www.ebi.ac.uk/pdbsum/3zq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zq6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ARSA_METTH ARSA_METTH] Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Eukaryotic tail-anchored (TA) membrane proteins are inserted into the endoplasmic reticulum by a post-translational TRC40 pathway, but no comparable pathway is known in other domains of life. The crystal structure of an archaebacterial TRC40 sequence homolog bound to ADP*AlF(4) (-) reveals characteristic features of eukaryotic TRC40 including a zinc-mediated dimer and a large hydrophobic groove. Moreover, archaeal TRC40 interacts with the transmembrane domain of TA substrates and directs their membrane insertion. Thus, the TRC40 pathway is more broadly conserved than previously recognized. | ||
| - | + | A conserved archaeal pathway for tail-anchored membrane protein insertion.,Sherrill J, Mariappan M, Dominik P, Hegde RS, Keenan RJ Traffic. 2011 Jun 9. doi: 10.1111/j.1600-0854.2011.01229.x. PMID:21658170<ref>PMID:21658170</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3zq6" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Methanothermobacter thermautotrophicus]] | ||
| + | [[Category: Dominik P]] | ||
| + | [[Category: Hegde RS]] | ||
| + | [[Category: Keenan RJ]] | ||
| + | [[Category: Mariappan M]] | ||
| + | [[Category: Sherrill J]] | ||
Current revision
ADP-ALF4 COMPLEX OF M. THERM. TRC40
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