2f40

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(New page: 200px<br /><applet load="2f40" size="350" color="white" frame="true" align="right" spinBox="true" caption="2f40" /> '''Structure of a Novel Protein from Backbone-C...)
Current revision (06:40, 1 May 2024) (edit) (undo)
 
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[[Image:2f40.gif|left|200px]]<br /><applet load="2f40" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2f40" />
 
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'''Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction'''<br />
 
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==Overview==
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==Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction==
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Targeting of proteins for structure determination in structural genomic, programs often includes the use of threading and fold recognition methods, to exclude proteins belonging to well-populated fold families, but such, methods can still fail to recognize preexisting folds. The authors, illustrate here a method in which limited amounts of structural data are, used to improve an initial homology search and the data are subsequently, used to produce a structure by data-constrained refinement of an, identified structural template. The data used are primarily NMR-based, residual dipolar couplings, but they also include additional chemical, shift and backbone-nuclear Overhauser effect data. Using this methodology, a backbone structure was efficiently produced for a 10 kDa protein, (PF1455) from Pyrococcus furiosus. Its relationship to existing structures, and its probable function are discussed.
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<StructureSection load='2f40' size='340' side='right'caption='[[2f40]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2f40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F40 FirstGlance]. <br>
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2F40 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F40 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f40 OCA], [https://pdbe.org/2f40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f40 RCSB], [https://www.ebi.ac.uk/pdbsum/2f40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f40 ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structure determination of a new protein from backbone-centered NMR data and NMR-assisted structure prediction., Mayer KL, Qu Y, Bansal S, LeBlond PD, Jenney FE Jr, Brereton PS, Adams MW, Xu Y, Prestegard JH, Proteins. 2006 Nov 1;65(2):480-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16927360 16927360]
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== Function ==
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[[Category: Pyrococcus furiosus]]
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[https://www.uniprot.org/uniprot/Q8U0X6_PYRFU Q8U0X6_PYRFU]
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[[Category: Single protein]]
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__TOC__
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[[Category: Bansal, S.]]
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</StructureSection>
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[[Category: Prestegard, J.H.]]
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[[Category: Large Structures]]
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[[Category: SECSG, Southeast.Collaboratory.for.Structural.Genomics.]]
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[[Category: Pyrococcus furiosus DSM 3638]]
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[[Category: protein structure initiative]]
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[[Category: Bansal S]]
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[[Category: protein structure prediction]]
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[[Category: Prestegard JH]]
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[[Category: psi]]
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[[Category: pyrococcus furious]]
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[[Category: residual dipolar couplings]]
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[[Category: secsg]]
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[[Category: simulated annealing]]
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[[Category: southeast collaboratory for structural genomics]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:27:00 2008''
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Current revision

Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction

PDB ID 2f40

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