3nea

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[[Image:3nea.jpg|left|200px]]
 
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==Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis==
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The line below this paragraph, containing "STRUCTURE_3nea", creates the "Structure Box" on the page.
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<StructureSection load='3nea' size='340' side='right'caption='[[3nea]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3nea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis Francisella tularensis subsp. tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NEA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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{{STRUCTURE_3nea| PDB=3nea | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [https://pdbe.org/3nea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [https://www.ebi.ac.uk/pdbsum/3nea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nea ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTH_FRATT PTH_FRATT] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The rational design of novel antibiotics for bacteria involves the identification of inhibitors for enzymes involved in essential biochemical pathways in cells. In this study, the cloning, expression, purification, crystallization and structure of the enzyme peptidyl-tRNA hydrolase from Francisella tularensis, the causative agent of tularemia, was performed. The structure of F. tularensis peptidyl-tRNA hydrolase is comparable to those of other bacterial peptidyl-tRNA hydrolases, with most residues in the active site conserved amongst the family. The resultant reagents, structural data and analyses provide essential information for the structure-based design of novel inhibitors for this class of proteins.
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===Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis===
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Structure of Francisella tularensis peptidyl-tRNA hydrolase.,Clarke TE, Romanov V, Lam R, Gothe SA, Peddi SR, Razumova EB, Lipman RS, Branstrom AA, Chirgadze NY Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt, 4):446-9. Epub 2011 Mar 26. PMID:21505237<ref>PMID:21505237</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3nea" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21505237}}, adds the Publication Abstract to the page
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*[[Peptidyl-tRNA hydrolase|Peptidyl-tRNA hydrolase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21505237 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21505237}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3nea]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis Francisella tularensis subsp. tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA].
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==Reference==
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<ref group="xtra">PMID:021505237</ref><references group="xtra"/>
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[[Category: Aminoacyl-tRNA hydrolase]]
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[[Category: Francisella tularensis subsp. tularensis]]
[[Category: Francisella tularensis subsp. tularensis]]
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[[Category: Branstrom, A A.]]
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[[Category: Large Structures]]
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[[Category: Chirgadze, N Y.]]
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[[Category: Branstrom AA]]
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[[Category: Gothe, S A.]]
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[[Category: Chirgadze NY]]
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[[Category: Lam, R.]]
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[[Category: Gothe SA]]
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[[Category: Lipman, R S.]]
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[[Category: Lam R]]
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[[Category: McGrath, T E.]]
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[[Category: Lipman RS]]
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[[Category: Peddi, S R.]]
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[[Category: McGrath TE]]
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[[Category: Razumova, E.]]
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[[Category: Peddi SR]]
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[[Category: Romanov, V.]]
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[[Category: Razumova E]]
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[[Category: Hydrolase]]
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[[Category: Romanov V]]
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[[Category: Peptidyl-trna]]
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Current revision

Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis

PDB ID 3nea

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