2f4s

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(New page: 200px<br /><applet load="2f4s" size="350" color="white" frame="true" align="right" spinBox="true" caption="2f4s, resolution 2.800&Aring;" /> '''A-site RNA in compl...)
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[[Image:2f4s.gif|left|200px]]<br /><applet load="2f4s" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2f4s, resolution 2.800&Aring;" />
 
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'''A-site RNA in complex with neamine'''<br />
 
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==Overview==
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==A-site RNA in complex with neamine==
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The X-ray crystal structures for the complexes of three designer, antibiotics, compounds 1, 2, and 3, bound to two models for the ribosomal, aminoacyl-tRNA site (A site) at 2.5-3.0 Angstroms resolution and that of, neamine at 2.8 Angstroms resolution are described. Furthermore, the, complex of antibiotic 1 bound to the A site in the entire 30S ribosomal, subunit of Thermus thermophilus is reported at 3.8 Angstroms resolution., Molecular dynamics simulations revealed that the designer compounds, provide additional stability to bases A1492 and A1493 in their, extrahelical forms. Snapshots from the simulations were used for free, energy calculations, which revealed that van der Waals and hydrophobic, effects were the driving forces behind the binding of designer antibiotic, 3 when compared to the parental neamine.
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<StructureSection load='2f4s' size='340' side='right'caption='[[2f4s]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2f4s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F4S FirstGlance]. <br>
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2F4S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=XXX:'>XXX</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F4S OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XXX:(2R,3S,4R,5R,6R)-6-((1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYLOXY)-5-AMINO-2-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-3,4-DIOL'>XXX</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f4s OCA], [https://pdbe.org/2f4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f4s RCSB], [https://www.ebi.ac.uk/pdbsum/2f4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f4s ProSAT]</span></td></tr>
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Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site., Murray JB, Meroueh SO, Russell RJ, Lentzen G, Haddad J, Mobashery S, Chem Biol. 2006 Feb;13(2):129-38. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16492561 16492561]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Haddad, J.]]
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</StructureSection>
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[[Category: Lentzen, G.]]
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[[Category: Large Structures]]
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[[Category: Meroueh, S.O.]]
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[[Category: Haddad J]]
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[[Category: Mobashery, S.]]
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[[Category: Lentzen G]]
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[[Category: Murray, J.B.]]
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[[Category: Meroueh SO]]
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[[Category: Russell, R.J.]]
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[[Category: Mobashery S]]
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[[Category: XXX]]
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[[Category: Murray JB]]
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[[Category: a-site rna]]
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[[Category: Russell RJ]]
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[[Category: neamine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:27:31 2008''
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Current revision

A-site RNA in complex with neamine

PDB ID 2f4s

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