2f87

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(New page: 200px<br /><applet load="2f87" size="350" color="white" frame="true" align="right" spinBox="true" caption="2f87" /> '''Solution structure of a GAAG tetraloop in SR...)
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[[Image:2f87.gif|left|200px]]<br /><applet load="2f87" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2f87" />
 
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'''Solution structure of a GAAG tetraloop in SRP RNA from Pyrococcus furiosus'''<br />
 
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==Overview==
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==Solution structure of a GAAG tetraloop in SRP RNA from Pyrococcus furiosus==
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The NMR structure of a 12-mer RNA derived from the helix 6 of SRP RNA from, Pyrococcus furiosus, whose loop-closing base pair is U.G, was determined, and the structural and thermodynamic properties of the RNA were compared, with those of a mutant RNA with the C:G closing base pair. Although the, structures of the two RNAs are similar to each other and adopt the GNRR, motif the conformational stabilities are significantly different to each, other It was suggested that weaker stacking interaction of the GAAG loop, with the U:G closing base pair in 12-mer RNA causes the lower, conformational stability.
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<StructureSection load='2f87' size='340' side='right'caption='[[2f87]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2f87]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F87 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f87 OCA], [https://pdbe.org/2f87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f87 RCSB], [https://www.ebi.ac.uk/pdbsum/2f87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f87 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The NMR structure of a 12-mer RNA derived from the helix 6 of SRP RNA from Pyrococcus furiosus, whose loop-closing base pair is U.G, was determined, and the structural and thermodynamic properties of the RNA were compared with those of a mutant RNA with the C:G closing base pair. Although the structures of the two RNAs are similar to each other and adopt the GNRR motif the conformational stabilities are significantly different to each other It was suggested that weaker stacking interaction of the GAAG loop with the U:G closing base pair in 12-mer RNA causes the lower conformational stability.
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==About this Structure==
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Solution structure of a GAAG tetraloop in helix 6 of SRP RNA from Pyrococcus furiosus.,Okada K, Takahashi M, Sakamoto T, Kawai G, Nakamura K, Kanai A Nucleosides Nucleotides Nucleic Acids. 2006;25(4-6):383-95. PMID:16838833<ref>PMID:16838833</ref>
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2F87 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F87 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of a GAAG tetraloop in helix 6 of SRP RNA from Pyrococcus furiosus., Okada K, Takahashi M, Sakamoto T, Kawai G, Nakamura K, Kanai A, Nucleosides Nucleotides Nucleic Acids. 2006;25(4-6):383-95. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16838833 16838833]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 2f87" style="background-color:#fffaf0;"></div>
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[[Category: Kanai, A.]]
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== References ==
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[[Category: Kawai, G]]
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<references/>
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[[Category: Nakamura, K.]]
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__TOC__
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[[Category: Okada, K.]]
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</StructureSection>
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[[Category: Sakamoto, T.]]
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[[Category: Large Structures]]
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[[Category: Takahashi, M.]]
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[[Category: Kanai A]]
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[[Category: gnrr]]
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[[Category: Kawai G]]
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[[Category: rna]]
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[[Category: Nakamura K]]
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[[Category: srp]]
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[[Category: Okada K]]
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[[Category: Sakamoto T]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:29:58 2008''
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[[Category: Takahashi M]]

Current revision

Solution structure of a GAAG tetraloop in SRP RNA from Pyrococcus furiosus

PDB ID 2f87

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