Neurexin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:35, 7 November 2019) (edit) (undo)
 
(26 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3bod.png|left|200px|thumb|Crystal Structure of mouse β-neurexin 1 [[3bod]]]]
+
<StructureSection load='' size='350' side='right' caption='Glycosylated rat neurexin 1α LNS domain (cyan) complex with neuroligin-4 cholinesterase domain (pink), MES, ethylene glycol, Cl- and Ca+2 ions (PDB entry [[2xb6]])' scene='42/424006/Cv/2'>
-
{{STRUCTURE_3bod| PDB=3bod | SIZE=300| SCENE=Neurexin/Cv/1 |right|CAPTION=Mouse β-neurexin 1 [[3bod]] }}
+
__TOC__
 +
== Function ==
 +
[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4<ref>PMID:12796785</ref>. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6.
-
[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. The images at the left and at the right correspond to one representative NRXN, ''i.e.'' the crystal structure of mouse β-neurexin 1 ([[3bod]]).
+
See: [[Neurodevelopmental Disorders]]<br />
 +
[[Neuroligin-Neurexin Interaction]]
-
For Structural Analysis of Neurexin, See: [[Neuroligin-Neurexin Interaction]]
+
== Relevance ==
 +
NRXN sequence variants may contribute to autism spectrum disorder and other cognitive diseases<ref>PMID:18179900</ref>.
 +
== Structural highlights ==
 +
The <scene name='42/424006/Cv/7'>surface interaction between NRXN and neuroligin</scene> is mediated by a <scene name='42/424006/Cv/8'>Ca+2 ion</scene><ref>PMID:20543817</ref>. Water molecules are shown as red spheres.
-
{{TOC limit|limit=2}}
+
</StructureSection>
== 3D Structures of Neurexin ==
== 3D Structures of Neurexin ==
-
''Update June 2011''
+
{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
 +
*Neurexin
-
=== α-NRXN ===
+
**[[5z8y]] – hNRXN-1b + LRRTM2 – human<br />
-
 
+
**[[3mw2]] – mNRXN-1α LNS domain+splice insert 4 – mouse<br />
-
 
+
**[[3bod]], [[3bop]] - mβNRXN-1 residues 1132-1246 + mb-NRXN-2 residues 1277-1334<br />
-
[[2h0b]] - bα-NRXN-1 LNS2 – bovine<br />
+
**[[3mw4]] - mβNRXN-3 residues 854-1027<br />
-
[[2r16]] - bα-NRXN-1 LNS 4<br />
+
**[[6pnp]], [[6pnq]] - mNRXN-1 LNS2 domain + neurexophilin-1<br />
-
 
+
**[[3mw3]], [[2r1b]] - rNRXN-1α LNS domain+splice insert 4 – rat<br />
-
 
+
**[[2r16]] - rNRXN-1α LNS domain+Ca<br />
-
=== β-NRXN ===
+
**[[1c4r]] - rNRXN-1α LNS domain<br />
-
 
+
**[[2r1d]] - rNRXN-1β LNS/LG domain<br />
-
 
+
**[[2h0b]] - bNRXN-1α LNS2 domain – bovine<br />
-
[[3mw2]] – mβ-NRXN-1 +splice insert 4 – mouse<br />
+
**[[6cw1]] - bNRXN-1 LNS2-LNS3 domains<br />
-
[[3bod]] - mβ-NRXN-1<br />
+
**[[3asi]] - bNRXN-1α LNS5-EGF3-LNS6 domains<br />
-
[[3bop]] - mβ-NRXN-2d4<br />
+
**[[3poy]] - bNRXN-1α LNS2-LNS6 domains (mutant)<br />
-
[[3mw3]], [[2r1b]] - rβ-NRXN-2 +splice insert 4 – rat<br />
+
**[[3qcw]], [[3r05]] - bNRXN-1α LNS1-LNS6 domains (mutant)<br />
-
[[2r1b]] - rβ-NRXN-1 +splice insert 4<br />
+
-
[[2r1d]] - rβ-NRXN-1 +Ca<br />
+
-
[[1c4r]] - rβ-NRXN-1<br />
+
-
[[3mw4]] - mβ-NRXN-3<br />
+
-
 
+
-
 
+
-
 
+
-
 
+
-
=== NRXN+NLGN ===
+
-
+
-
 
+
-
[[2xb6]], [[2wqz]] – rβ-NRXN-1 +hNLGN-4 cholinesterase domain<br />
+
-
[[3b3q]] - hNRXN-1 LNS domain+mNLGN-1 cholinesterase domain<br />
+
-
[[3biw]] - rβ-NRXN-1 +rNLGN-1 cholinesterase domain<br />
+
-
 
+
-
===NRXN===
+
-
 
+
-
[[3mw2]] – mNRXN-1α LNS domain+splice insert 4 – mouse<br />
+
-
[[3bod]], [[3bop]] - mNRXN-1α LNS domain<br />
+
-
[[3mw3]], [[2r1b]] - rNRXN-1α LNS domain+splice insert 4 – rat<br />
+
-
[[2r16]] - rNRXN-1α LNS domain+Ca<br />
+
-
[[1c4r]] - rNRXN-1α LNS domain<br />
+
-
[[3mw4]] - mNRXN-1α LNS domain<br />
+
-
[[2h0b]] - bNRXN-1α LNS2 domain – bovine<br />
+
-
[[3asi]] - bNRXN-1α LNS25-EGF3-LNS6 domains<br />
+
-
 
+
-
===NRXN+NLGN===
+
-
 
+
-
[[2xb6]], [[2wqz]] – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain<br />
+
-
[[3b3q]] - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain<br />
+
-
[[3biw]] - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain<br />
+
 +
*NRXN+Neuroligin
 +
**[[2xb6]], [[2wqz]] – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain<br />
 +
**[[3b3q]] - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain<br />
 +
**[[3biw]] - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain<br />
 +
**[[3vkf]] - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain
 +
}}
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Glycosylated rat neurexin 1α LNS domain (cyan) complex with neuroligin-4 cholinesterase domain (pink), MES, ethylene glycol, Cl- and Ca+2 ions (PDB entry 2xb6)

Drag the structure with the mouse to rotate

3D Structures of Neurexin

07-November-2019

References

  1. ↑ Dean C, Scholl FG, Choih J, DeMaria S, Berger J, Isacoff E, Scheiffele P. Neurexin mediates the assembly of presynaptic terminals. Nat Neurosci. 2003 Jul;6(7):708-16. PMID:12796785 doi:http://dx.doi.org/10.1038/nn1074
  2. ↑ Kim HG, Kishikawa S, Higgins AW, Seong IS, Donovan DJ, Shen Y, Lally E, Weiss LA, Najm J, Kutsche K, Descartes M, Holt L, Braddock S, Troxell R, Kaplan L, Volkmar F, Klin A, Tsatsanis K, Harris DJ, Noens I, Pauls DL, Daly MJ, MacDonald ME, Morton CC, Quade BJ, Gusella JF. Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet. 2008 Jan;82(1):199-207. doi: 10.1016/j.ajhg.2007.09.011. PMID:18179900 doi:http://dx.doi.org/10.1016/j.ajhg.2007.09.011
  3. ↑ Leone P, Comoletti D, Ferracci G, Conrod S, Garcia SU, Taylor P, Bourne Y, Marchot P. Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. EMBO J. 2010 Jul 21;29(14):2461-71. Epub 2010 Jun 11. PMID:20543817 doi:10.1038/emboj.2010.123
Retrieved from "http://52.214.119.220/wiki/index.php/Neurexin"
Personal tools