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Phage integrase

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[[Image:1z1g.png|left|200px|thumb|Crystal Structure of Enterobacteria phage λ integrase [[1z1g]]]]
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<StructureSection load='' size='400' side='right' scene='44/443479/Cv/2' caption='Se-Met Enterobacteria phage λ integrase:DNA tetramer complex (Holiday Junction) [[1z1g]]' pspeed='8'>
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{{STRUCTURE_1z1g| PDB=1z1g | SIZE=300| SCENE=Phage_integrase/Cv/1 |right|CAPTION= Enterobacteria phage λ integrase:DNA complex (Holiday Junction) [[1z1g]] }}
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'''Phage integrase''' (PIN) mediates recombination between DNA recognition sequences - the phage attachment site attP and the bacterial attachment site attB<ref>PMID:14687564</ref>. The '''Tyrosine family PIN''' uses a catalytic tyrosine to mediate strand cleavage while the '''Serine family PIN''' uses a serine residue. The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria.
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*The biological assembly of Enterobacteria phage λ integrase is <scene name='44/443479/Cv/3'>homotetramer</scene>.
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</StructureSection>
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== 3D Structures of phage integrase see [[Retroviral Integrase]]==
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'''Phage integrase''' (PIN) mediate recombination between DNA recognition sequences - the phage attP and the bacterial attB. The Tyrosine family PIN uses a catalytic tyrosine to mediate strand cleavage while the Serine family PIN uses a serine residue. The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria.
 
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{{TOC limit|limit=2}}
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== References ==
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<references/>
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== 3D Structures of phage integrase ==
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''Update June 2011''
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[[3nrw]] – PIN/site-specific recombinase N-terminal – ''Haloarcula marismortui''<br />
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[[3jtz]] – PIN arm-type binding domain – ''Yersinia pestis''<br />
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[[3ju0]] – HPI PIN arm-type binding domain – ''Pectobacterium atrosepticum''<br />
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[[2kkp]] – PIN SAM-like domain – ''Moorella thermoacetica'' – NMR<br />
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[[2kkv]] – PIN fragment – ''Salmonella enterica'' – NMR<br />
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[[2khq]] - PIN fragment – ''Staphylococcus saprophyticus'' – NMR<br />
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[[2wcc]] – λPIN DBD+ DNA – Enterobacteria phage λ - NMR<br />
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[[1kjk]] – λPIN N-terminal - NMR<br />
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[[2oxo]], [[1z19]], [[1z1b]] - λPIN core binding domain + DNA<br />
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[[1ae9]] - λPIN catalytic core domain (mutant) <br />
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[[1z1g]] – λPIN + DNA (Holliday junction)<br />
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[[1p7d]] – λPIN fragment + DNA <br />
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[[3bvp]] – PIN catalytic core domain – Lactococcus phage TP101-1<br />
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[[1aih]] - PIN catalytic core domain – Haemophilus phage HP1<br />
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[[2khv]], [[2kj5]] – PIN residues 102-199 – ''Nitrosospira multiformis'' - NMR
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Se-Met Enterobacteria phage λ integrase:DNA tetramer complex (Holiday Junction) 1z1g

Drag the structure with the mouse to rotate

3D Structures of phage integrase see Retroviral Integrase

References

  1. ↑ Groth AC, Calos MP. Phage integrases: biology and applications. J Mol Biol. 2004 Jan 16;335(3):667-78. PMID:14687564 doi:http://dx.doi.org/10.1016/S0022283603013561

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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