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3qp9

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[[Image:3qp9.png|left|200px]]
 
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==The Structure of a C2-type Ketoreductase from a Modular Polyketide Synthase==
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The line below this paragraph, containing "STRUCTURE_3qp9", creates the "Structure Box" on the page.
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<StructureSection load='3qp9' size='340' side='right'caption='[[3qp9]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qp9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QP9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qp9 OCA], [https://pdbe.org/3qp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qp9 RCSB], [https://www.ebi.ac.uk/pdbsum/3qp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qp9 ProSAT]</span></td></tr>
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{{STRUCTURE_3qp9| PDB=3qp9 | SCENE= }}
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</table>
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== Function ==
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===The Structure of a C2-type Ketoreductase from a Modular Polyketide Synthase===
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[https://www.uniprot.org/uniprot/PIKA2_STRVZ PIKA2_STRVZ] Involved in the biosynthesis of 12- and 14-membered ring macrolactone antibiotics such as methymycin/neomethymycin and pikromycin/narbomycin, respectively. Component of the pikromycin PKS which catalyzes the biosynthesis of both precursors 10-deoxymethynolide (12-membered ring macrolactone) and narbonolide (14-membered ring macrolactone). Chain elongation through PikAI, PikAII and PikAIII followed by thioesterase catalyzed termination results in the production of 10-deoxymethynolide, while continued elongation through PikAIV, followed by thioesterase (TE) catalyzed cyclization results in the biosynthesis of the narbonolide.<ref>PMID:10421766</ref> <ref>PMID:21570406</ref> <ref>PMID:19027305</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21570406 is the PubMed ID number.
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_21570406}}
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==About this Structure==
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[[3qp9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QP9 OCA].
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==Reference==
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<ref group="xtra">PMID:021570406</ref><references group="xtra"/>
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[[Category: Streptomyces venezuelae]]
[[Category: Streptomyces venezuelae]]
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[[Category: Keatinge-Clay, A T.]]
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[[Category: Keatinge-Clay AT]]
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[[Category: Zheng, J.]]
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[[Category: Zheng J]]
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[[Category: Epimerization]]
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[[Category: Ketoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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Current revision

The Structure of a C2-type Ketoreductase from a Modular Polyketide Synthase

PDB ID 3qp9

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