3sfi

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m (Protected "3sfi" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 3sfi is ON HOLD
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==Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.==
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<StructureSection load='3sfi' size='340' side='right'caption='[[3sfi]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sfi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SFI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SF:5,5,5-TRIFLUORO-1-{4-[3-(1,3-THIAZOL-2-YL)-1,2,4-OXADIAZOL-5-YL]PIPERIDIN-1-YL}PENTAN-1-ONE'>3SF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfi OCA], [https://pdbe.org/3sfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sfi RCSB], [https://www.ebi.ac.uk/pdbsum/3sfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sfi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
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Authors: Flipo, M., Desroses, M., Lecat-Guillet, N., Villemagne, B., Blondiaux, N., Leroux, F., Piveteau, C., Mathys, V., Flament, M.P., Siepmann, J., Villeret, V., Wohlkonig, A., Wintjens, R., Soror, S.H., Christophe, T., Jeon, H.K., Locht, C., Brodin, P., D prez, B, Baulard, A.R., Willand, N
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==See Also==
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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Description: Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Baulard AR]]
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[[Category: Blondiaux N]]
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[[Category: Brodin P]]
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[[Category: Christophe T]]
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[[Category: D prez B]]
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[[Category: Desroses M]]
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[[Category: Flament MP]]
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[[Category: Flipo M]]
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[[Category: Jeon HK]]
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[[Category: Lecat-Guillet N]]
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[[Category: Leroux F]]
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[[Category: Locht C]]
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[[Category: Mathys V]]
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[[Category: Piveteau C]]
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[[Category: Siepmann J]]
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[[Category: Soror SH]]
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[[Category: Villemagne B]]
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[[Category: Villeret V]]
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[[Category: Willand N]]
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[[Category: Wintjens R]]
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[[Category: Wohlkonig A]]

Current revision

Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.

PDB ID 3sfi

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OCA

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