3rt0

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[[Image:3rt0.jpg|left|200px]]
 
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==Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)==
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The line below this paragraph, containing "STRUCTURE_3rt0", creates the "Structure Box" on the page.
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<StructureSection load='3rt0' size='340' side='right'caption='[[3rt0]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rt0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.113&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3rt0| PDB=3rt0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt0 OCA], [https://pdbe.org/3rt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt0 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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PYR1/PYL/RCAR proteins (PYLs) are confirmed abscisic acid (ABA) receptors, which inhibit protein phosphatase 2C (PP2C) upon binding to ABA. Arabidopsis thaliana has 14 PYLs, yet their functional distinction remains unclear. Here, we report systematic biochemical characterization of PYLs. A subclass of PYLs, represented by PYL10, inhibited PP2C in the absence of any ligand. Crystal structures of PYL10, both in the free form and in the HAB1 (PP2C)-bound state, revealed the structural basis for its constitutive activity. Structural-guided biochemical analyses revealed that ABA-independent inhibition of PP2C requires the PYLs to exist in a monomeric state. In addition, the residues guarding the entrance to the ligand-binding pocket of these PYLs should be bulky and hydrophobic. Based on these principles, we were able to generate monomeric PYL2 variants that gained constitutive inhibitory effect on PP2Cs. These findings provide an important framework for understanding the complex regulation of ABA signaling by PYL proteins.
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===Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)===
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The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins.,Hao Q, Yin P, Li W, Wang L, Yan C, Lin Z, Wu JZ, Wang J, Yan SF, Yan N Mol Cell. 2011 Jun 10;42(5):662-72. PMID:21658606<ref>PMID:21658606</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rt0" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21658606}}, adds the Publication Abstract to the page
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*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21658606 is the PubMed ID number.
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_21658606}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3rt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT0 OCA].
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==Reference==
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<ref group="xtra">PMID:021658606</ref><references group="xtra"/>
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Hao, Q.]]
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[[Category: Hao Q]]
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[[Category: Li, W.]]
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[[Category: Li W]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: Wang, L.]]
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[[Category: Wang L]]
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[[Category: Yan, C.]]
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[[Category: Yan C]]
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[[Category: Yan, N.]]
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[[Category: Yan N]]
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[[Category: Yin, P.]]
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[[Category: Yin P]]
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[[Category: Apo-pyl10 inhibits hab1 dephosphorylation activity]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Pyl10-hab1 binary complex]]
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Current revision

Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)

PDB ID 3rt0

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