3rt2

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[[Image:3rt2.jpg|left|200px]]
 
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==Crystal structure of apo-PYL10==
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The line below this paragraph, containing "STRUCTURE_3rt2", creates the "Structure Box" on the page.
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<StructureSection load='3rt2' size='340' side='right'caption='[[3rt2]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rt2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt2 OCA], [https://pdbe.org/3rt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt2 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt2 ProSAT]</span></td></tr>
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{{STRUCTURE_3rt2| PDB=3rt2 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYL10_ARATH PYL10_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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PYR1/PYL/RCAR proteins (PYLs) are confirmed abscisic acid (ABA) receptors, which inhibit protein phosphatase 2C (PP2C) upon binding to ABA. Arabidopsis thaliana has 14 PYLs, yet their functional distinction remains unclear. Here, we report systematic biochemical characterization of PYLs. A subclass of PYLs, represented by PYL10, inhibited PP2C in the absence of any ligand. Crystal structures of PYL10, both in the free form and in the HAB1 (PP2C)-bound state, revealed the structural basis for its constitutive activity. Structural-guided biochemical analyses revealed that ABA-independent inhibition of PP2C requires the PYLs to exist in a monomeric state. In addition, the residues guarding the entrance to the ligand-binding pocket of these PYLs should be bulky and hydrophobic. Based on these principles, we were able to generate monomeric PYL2 variants that gained constitutive inhibitory effect on PP2Cs. These findings provide an important framework for understanding the complex regulation of ABA signaling by PYL proteins.
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===Crystal structure of apo-PYL10===
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The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins.,Hao Q, Yin P, Li W, Wang L, Yan C, Lin Z, Wu JZ, Wang J, Yan SF, Yan N Mol Cell. 2011 Jun 10;42(5):662-72. PMID:21658606<ref>PMID:21658606</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rt2" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21658606}}, adds the Publication Abstract to the page
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*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21658606 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21658606}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3rt2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT2 OCA].
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==Reference==
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<ref group="xtra">PMID:021658606</ref><references group="xtra"/>
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Hao, Q.]]
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[[Category: Large Structures]]
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[[Category: Li, W.]]
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[[Category: Hao Q]]
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[[Category: Wang, J.]]
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[[Category: Li W]]
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[[Category: Wang, L.]]
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[[Category: Wang J]]
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[[Category: Yan, C.]]
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[[Category: Wang L]]
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[[Category: Yan, N.]]
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[[Category: Yan C]]
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[[Category: Yin, P.]]
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[[Category: Yan N]]
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[[Category: Aba receptor]]
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[[Category: Yin P]]
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[[Category: Aba-independent pp2c inhibitor]]
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[[Category: Abscisic acid]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Pp2c]]
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[[Category: Pyl10]]
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Current revision

Crystal structure of apo-PYL10

PDB ID 3rt2

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