2xrd

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[[Image:2xrd.jpg|left|200px]]
 
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==Structure of the N-terminal four domains of the complement regulator Rat Crry==
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The line below this paragraph, containing "STRUCTURE_2xrd", creates the "Structure Box" on the page.
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<StructureSection load='2xrd' size='340' side='right'caption='[[2xrd]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xrd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrd OCA], [https://pdbe.org/2xrd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrd RCSB], [https://www.ebi.ac.uk/pdbsum/2xrd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrd ProSAT]</span></td></tr>
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{{STRUCTURE_2xrd| PDB=2xrd | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CR1L_RAT CR1L_RAT] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance.<ref>PMID:15474557</ref> <ref>PMID:7534798</ref> <ref>PMID:8144902</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Complement receptor 1-related protein Y (CrrY) is an important cell-surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70 degrees bend between domains 3 and 4. Comparisons of this structure with those of other complement regulators suggests that rearrangement of this interface may occur on forming the regulatory complex with C3b.
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===STRUCTURE OF THE N-TERMINAL FOUR DOMAINS OF THE COMPLEMENT REGULATOR RAT CRRY===
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Structures of the rat complement regulator CrrY.,Roversi P, Johnson S, Caesar JJ, McLean F, Leath KJ, Tsiftsoglou SA, Morgan BP, Harris CL, Sim RB, Lea SM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):739-43., Epub 2011 Jun 23. PMID:21795784<ref>PMID:21795784</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[2xrd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRD OCA].
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<div class="pdbe-citations 2xrd" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Johnson, S.]]
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[[Category: Johnson S]]
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[[Category: Lea, S M.]]
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[[Category: Lea SM]]
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[[Category: Leath, K J.]]
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[[Category: Leath KJ]]
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[[Category: Morgan, B P.]]
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[[Category: Morgan BP]]
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[[Category: Roversi, P.]]
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[[Category: Roversi P]]
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[[Category: Extracellular protein]]
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[[Category: Immune system]]
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Current revision

Structure of the N-terminal four domains of the complement regulator Rat Crry

PDB ID 2xrd

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