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3aqy

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[[Image:3aqy.jpg|left|200px]]
 
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==Crystal structure of Plodia interpunctella beta-GRP/GNBP3 N-terminal domain==
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The line below this paragraph, containing "STRUCTURE_3aqy", creates the "Structure Box" on the page.
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<StructureSection load='3aqy' size='340' side='right'caption='[[3aqy]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3aqy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plodia_interpunctella Plodia interpunctella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AQY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aqy OCA], [https://pdbe.org/3aqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aqy RCSB], [https://www.ebi.ac.uk/pdbsum/3aqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aqy ProSAT]</span></td></tr>
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{{STRUCTURE_3aqy| PDB=3aqy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BGBP_PLOIN BGBP_PLOIN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Innate ability to detect pathogens is achieved by pattern recognition receptors (PRRs) which recognise non-self components such as beta1,3-glucan. beta1,3-Glucans form a triple-helical structure stabilised by inter-chain hydrogen bonds. beta1,3-Glucan recognition protein (betaGRP)/gram-negative bacteria-binding protein 3 (GNBP3), one of PPRs, binds to long, structured beta1,3-glucan to initiate innate immune response. However, binding details and how specificity is achieved in such receptors remain important outstanding issues. We solved the crystal structures of the N-terminal beta1,3-glucan recognition domain of betaGRP/GNBP3 (betaGRP-N) in complex with the beta1,3-linked glucose hexamer, laminarihexaose. In the crystals, three structured laminarihexaoses simultaneously interact through six glucose residues (two from each chain) with one betaGRP-N. The spatial arrangement of the laminarihexaoses bound to betaGRP-N is almost identical to that of a beta1,3-glucan triplex. Therefore, our crystallographic structures together with site-directed mutagenesis data provide a structural basis for the unique recognition by such receptors of the triple-helix structure of beta1,3-glucan.
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===Crystal structure of Plodia interpunctella beta-GRP/GNBP3 N-terminal domain===
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Structural insights into recognition of triple-helical {beta}-glucan by insect fungal receptor.,Kanagawa M, Satoh T, Ikeda A, Adachi Y, Ohno N, Yamaguchi Y J Biol Chem. 2011 Jun 22. PMID:21697086<ref>PMID:21697086</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3aqy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plodia_interpunctella Plodia interpunctella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQY OCA].
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<div class="pdbe-citations 3aqy" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Plodia interpunctella]]
[[Category: Plodia interpunctella]]
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[[Category: Adachi, Y.]]
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[[Category: Adachi Y]]
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[[Category: Ikeda, A.]]
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[[Category: Ikeda A]]
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[[Category: Kanagawa, M.]]
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[[Category: Kanagawa M]]
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[[Category: Ohno, N.]]
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[[Category: Ohno N]]
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[[Category: Satoh, T.]]
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[[Category: Satoh T]]
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[[Category: Yamaguchi, Y.]]
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[[Category: Yamaguchi Y]]
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[[Category: 3-glucan]]
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[[Category: Beta-1]]
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[[Category: Beta-sandwich]]
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[[Category: Immune receptor]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal structure of Plodia interpunctella beta-GRP/GNBP3 N-terminal domain

PDB ID 3aqy

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