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Plectin

From Proteopedia

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(New page: <Structure load='1sh6' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><!-- Please use the "3D" button above this box to inse...)
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<Structure load='1sh6' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><!--
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<Structure load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '>
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Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
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== Function ==
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'''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain (residues 1492-1530), N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains (repeat#6 contains residues 4403-4606), and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprising of two calponin homology (CH) domains, plakin domain (residues 300-1372) and N-terminal arm, which varies among isoforms.
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Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure (1). C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3).
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For more details see [[Group:MUZIC:Plectin]].
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1. Foisner, R., and Wiche, G. (1987) J Mol Biol 198, 515-531
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==Disease ==
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2. Nikolic, B., Mac Nulty, E., Mir, B., and Wiche, G. (1996) J Cell Biol 134, 1455-1467
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Mutations in plectin result in skin fragility and blister formation<ref>PMID:15810881</ref>.
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3. Fuchs, P., Zorer, M., Rezniczek, G. A., Spazierer, D., Oehler, S., Castanon, M. J., Hauptmann, R., and Wiche, G. (1999) Hum Mol Genet 8, 2461-2472
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==3D structures of plectin==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1mb8]], [[4q59]] – hPCN actin-binding domain 59-293 – human<br />
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[[3pe0]] - hPCN plakin domain residues 747-918<br />
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[[2odu]], [[2odv]] – hPCN plakin domain residues 300-530 (mutant)<br />
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[[3pdy]] – hPCN plakin domain repeats 3-4 653-848<br />
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[[5j1g]] – hPCN plakin domain repeats 7-8 1004-1233<br />
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[[5j1f]], [[5j1h]] – hPCN plakin domain repeats 5-6 750-818, 889-1006<br />
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[[5j1i]] – hPCN plakin domain repeats 7-9 1104-1372<br />
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[[4gdo]] – hPCN rod domain 1382-1420<br />
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[[3f7p]], [[4q58]] - hPCN actin-binding domain + integrin β4 residues 1126-1370<br />
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[[4q57]] - hPCN actin-binding domain + calmodulin N terminal<br />
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[[2n03]] – hPCN C-terminal repeat domain 6 4403-4606 - NMR<br />
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[[1sh5]], [[1sh6]] - PCN actin-binding domain – mouse<br />
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== References ==
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<references/>
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[[Category:Topic Page]]

Current revision

Mouse plectin actin-binding domain 1sh6

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jae-Geun Song, Alexander Berchansky

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