3qfx

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[[Image:3qfx.jpg|left|200px]]
 
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==Trypanosoma brucei dihydrofolate reductase pyrimethamine complex==
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The line below this paragraph, containing "STRUCTURE_3qfx", creates the "Structure Box" on the page.
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<StructureSection load='3qfx' size='340' side='right'caption='[[3qfx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qfx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QFX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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{{STRUCTURE_3qfx| PDB=3qfx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qfx OCA], [https://pdbe.org/3qfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qfx RCSB], [https://www.ebi.ac.uk/pdbsum/3qfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qfx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DRTS_TRYBB DRTS_TRYBB] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
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===Trypanosoma brucei dihydrofolate reductase pyrimethamine complex===
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_21650210}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21650210 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21650210}}
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==About this Structure==
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[[3qfx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QFX OCA].
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==Reference==
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<ref group="xtra">PMID:021650210</ref><references group="xtra"/>
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[[Category: Dihydrofolate reductase]]
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[[Category: Trypanosoma brucei rhodesiense]]
[[Category: Trypanosoma brucei rhodesiense]]
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[[Category: Chitnumsub, P.]]
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[[Category: Chitnumsub P]]
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[[Category: Kamchonwongpaisan, S.]]
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[[Category: Kamchonwongpaisan S]]
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[[Category: Taweechai, S.]]
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[[Category: Taweechai S]]
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[[Category: Vanichtanankul, J.]]
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[[Category: Vanichtanankul J]]
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[[Category: Yuthavong, Y.]]
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[[Category: Yuthavong Y]]
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[[Category: Yuvaniyama, J.]]
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[[Category: Yuvaniyama J]]
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[[Category: Antifolate resistance]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Pyrimethamine]]
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[[Category: Trypanosome]]
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Current revision

Trypanosoma brucei dihydrofolate reductase pyrimethamine complex

PDB ID 3qfx

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OCA

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