3s7v

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[[Image:3s7v.jpg|left|200px]]
 
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==Unassembled KI Polyomavirus VP1 Pentamer==
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The line below this paragraph, containing "STRUCTURE_3s7v", creates the "Structure Box" on the page.
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<StructureSection load='3s7v' size='340' side='right'caption='[[3s7v]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3s7v]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_polyomavirus_3 Human polyomavirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S7V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7v OCA], [https://pdbe.org/3s7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s7v RCSB], [https://www.ebi.ac.uk/pdbsum/3s7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7v ProSAT]</span></td></tr>
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{{STRUCTURE_3s7v| PDB=3s7v | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VP1_POVKI VP1_POVKI] Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with sialic acids on the cell surface to provide virion attachment to target cell. Once attached, the virion is internalized by endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA (By similarity).
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===Unassembled KI Polyomavirus VP1 Pentamer===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Human polyomavirus 3]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21543504 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Neu U]]
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{{ABSTRACT_PUBMED_21543504}}
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[[Category: Stehle T]]
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==About this Structure==
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[[3s7v]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Ki_polyomavirus Ki polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7V OCA].
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==Reference==
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<ref group="xtra">PMID:021543504</ref><references group="xtra"/>
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[[Category: Ki polyomavirus]]
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[[Category: Neu, U.]]
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[[Category: Stehle, T.]]
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[[Category: Antiparallel beta sandwich]]
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[[Category: Jelly-roll]]
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[[Category: Major capsid protein]]
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[[Category: Viral protein]]
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Current revision

Unassembled KI Polyomavirus VP1 Pentamer

PDB ID 3s7v

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