3r5k

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[[Image:3r5k.jpg|left|200px]]
 
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==A designed redox-controlled caspase-7==
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The line below this paragraph, containing "STRUCTURE_3r5k", creates the "Structure Box" on the page.
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<StructureSection load='3r5k' size='340' side='right'caption='[[3r5k]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3r5k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R5K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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{{STRUCTURE_3r5k| PDB=3r5k | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r5k OCA], [https://pdbe.org/3r5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r5k RCSB], [https://www.ebi.ac.uk/pdbsum/3r5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r5k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
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===A designed redox-controlled caspase-7===
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==See Also==
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*[[Caspase 3D structures|Caspase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21674661 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21674661}}
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==About this Structure==
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[[3r5k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R5K OCA].
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==Reference==
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<ref group="xtra">PMID:021674661</ref><references group="xtra"/>
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[[Category: Caspase-7]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hardy, J A.]]
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[[Category: Large Structures]]
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[[Category: Witkowski, W A.]]
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[[Category: Hardy JA]]
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[[Category: Apoptosis]]
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[[Category: Witkowski WA]]
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[[Category: Caspase]]
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[[Category: Cystine aspartate protease]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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[[Category: Thiol protease]]
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[[Category: Zymogen]]
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Current revision

A designed redox-controlled caspase-7

PDB ID 3r5k

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OCA

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