We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2kmz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (01:08, 21 November 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2kmz.jpg|left|200px]]
 
-
<!--
+
==NMR Structure of hFn14==
-
The line below this paragraph, containing "STRUCTURE_2kmz", creates the "Structure Box" on the page.
+
<StructureSection load='2kmz' size='340' side='right'caption='[[2kmz]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2kmz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMZ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmz OCA], [https://pdbe.org/2kmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmz RCSB], [https://www.ebi.ac.uk/pdbsum/2kmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmz ProSAT]</span></td></tr>
-
{{STRUCTURE_2kmz| PDB=2kmz | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TNR12_HUMAN TNR12_HUMAN] Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.<ref>PMID:11728344</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
TWEAK (TNF homologue with weak apoptosis-inducing activity) and Fn14 (fibroblast growth factor-inducible protein 14) are members of the tumor necrosis factor (TNF) ligand and receptor super-families. Having observed that Xenopus Fn14 cross-reacts with human TWEAK, despite its relatively low sequence homology to human Fn14, we examined the conservation in tertiary fold and binding interfaces between the two species. Our results, combining NMR solution structure determination, binding assays, extensive site-directed mutagenesis and molecular modeling, reveal that, in addition to the known and previously characterized beta-hairpin motif, the helix-loop-helix motif makes an essential contribution to the receptor/ligand binding interface. We further discuss the insight provided by the structural analyses regarding how the cysteine-rich domains of the TNF receptor super-family may have evolved over time. DATABASE: Structural data are available in the Protein Data Bank/BioMagResBank databases under the accession codes 2KMZ, 2KN0 and 2KN1 and 17237, 17247 and 17252. STRUCTURED DIGITAL ABSTRACT: TWEAK binds to hFn14 by surface plasmon resonance (View interaction) xeFn14 binds to TWEAK by enzyme linked immunosorbent assay (View interaction) TWEAK binds to xeFn14 by surface plasmon resonance (View interaction) hFn14 binds to TWEAK by enzyme linked immunosorbent assay (View interaction).
-
===NMR Structure of hFn14===
+
Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.,Pellegrini M, Willen L, Perroud M, Krushinskie D, Strauch K, Cuervo H, Day ES, Schneider P, Zheng TS FEBS J. 2013 Feb 25. doi: 10.1111/febs.12206. PMID:23438059<ref>PMID:23438059</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2kmz" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[2kmz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMZ OCA].
+
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Cuervo, H.]]
+
[[Category: Large Structures]]
-
[[Category: Day, E S.]]
+
[[Category: Cuervo H]]
-
[[Category: Krushinskie, D.]]
+
[[Category: Day ES]]
-
[[Category: Pellegrini, M.]]
+
[[Category: Krushinskie D]]
-
[[Category: Perroud, M.]]
+
[[Category: Pellegrini M]]
-
[[Category: Schneider, P.]]
+
[[Category: Perroud M]]
-
[[Category: Strauch, K.]]
+
[[Category: Schneider P]]
-
[[Category: Sun, Y.]]
+
[[Category: Strauch K]]
-
[[Category: Willen, L.]]
+
[[Category: Sun Y]]
-
[[Category: Zheng, T S.]]
+
[[Category: Willen L]]
-
[[Category: Angiogenesis]]
+
[[Category: Zheng TS]]
-
[[Category: Apoptosis]]
+
-
[[Category: Cell adhesion]]
+
-
[[Category: Crd]]
+
-
[[Category: Developmental protein]]
+
-
[[Category: Differentiation]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Fn14]]
+
-
[[Category: Membrane]]
+
-
[[Category: Receptor]]
+
-
[[Category: Tnf receptor]]
+
-
[[Category: Tnfrsf12a]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Tweak]]
+

Current revision

NMR Structure of hFn14

PDB ID 2kmz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2kmz"
Personal tools