3nph

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3nph" [edit=sysop:move=sysop])
Current revision (00:33, 28 December 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3nph.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the pfam00427 domain from Synechocystis sp. PCC 6803==
-
The line below this paragraph, containing "STRUCTURE_3nph", creates the "Structure Box" on the page.
+
<StructureSection load='3nph' size='340' side='right'caption='[[3nph]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3nph]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NPH FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.849&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nph OCA], [https://pdbe.org/3nph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nph RCSB], [https://www.ebi.ac.uk/pdbsum/3nph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nph ProSAT]</span></td></tr>
-
{{STRUCTURE_3nph| PDB=3nph | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PYR2_SYNY3 PYR2_SYNY3] Rod linker protein, associated with phycocyanin. Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Phycobilisomes are light-harvesting supramolecular complexes in cyanobacteria and red algae. Linkers play a pivotal role in the assembly and energy transfer modulation of phycobilisomes. However, how linkers function remains unclear due to the lack of structural and biochemical studies of linkers, especially the N-terminal domain of L(R) (pfam00427). Here, we report the crystal structure of the pfam00427 domain of the linker L(R) (30) from Synechocystis sp. PCC 6803 at 1.9 A. The pfam00427 presents as a previously uncharacterized point symmetric six alpha-helix bundle. To elucidate the binding style of pfam00427 in the C-phycocyanin (C-PC) (alphabeta)(6) hexamer, we fixed pfam00427 computationally into the C-PC (alphabeta)(6) inner cavity using the program AutoDock. Combined with a conserved 'C-PC binding patch' on pfam00427 identified, we arrived at a model for the pfam00427-C-PC (alphabeta)(6) complex. This model was further optimized and evaluated as a reasonable result by a molecular dynamics simulation. In the resulting model, the pfam00427 domain is stably positioned in the central hole of the C-PC trimer. Moreover, the L(RT) (pfam01383) was docked into our pfam00427-C-PC model to generate a complete phycobilisome rod in which the linkers join individual biliprotein hexamers.
-
===Crystal structure of the pfam00427 domain from Synechocystis sp. PCC 6803===
+
Crystal structure of the N-terminal domain of linker L(R) and the assembly of cyanobacterial phycobilisome rods.,Gao X, Zhang N, Wei TD, Su HN, Xie BB, Dong CC, Zhang XY, Chen XL, Zhou BC, Wang ZX, Wu JW, Zhang YZ Mol Microbiol. 2011 Nov;82(3):698-705. doi:, 10.1111/j.1365-2958.2011.07844.x. Epub 2011 Oct 10. PMID:21923764<ref>PMID:21923764</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
==About this Structure==
+
</div>
-
[[3nph]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NPH OCA].
+
<div class="pdbe-citations 3nph" style="background-color:#fffaf0;"></div>
-
[[Category: Synechocystis sp.]]
+
== References ==
-
[[Category: Chen, L.]]
+
<references/>
-
[[Category: Gao, X.]]
+
__TOC__
-
[[Category: Wu, J W.]]
+
</StructureSection>
-
[[Category: Zhang, Y Z.]]
+
[[Category: Large Structures]]
-
[[Category: Linker protein]]
+
[[Category: Synechocystis sp. PCC 6803]]
-
[[Category: Pfam00427 domain]]
+
[[Category: Chen L]]
-
[[Category: Photosynthesis]]
+
[[Category: Gao X]]
-
[[Category: Phycobiliprotein]]
+
[[Category: Wu J-W]]
 +
[[Category: Zhang Y-Z]]

Current revision

Crystal structure of the pfam00427 domain from Synechocystis sp. PCC 6803

PDB ID 3nph

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3nph"
Personal tools