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3q7l

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[[Image:3q7l.jpg|left|200px]]
 
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==Crystal structure of the E2 domain of amyloid precursor-like protein 1==
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The line below this paragraph, containing "STRUCTURE_3q7l", creates the "Structure Box" on the page.
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<StructureSection load='3q7l' size='340' side='right'caption='[[3q7l]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q7l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3q7l| PDB=3q7l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7l OCA], [https://pdbe.org/3q7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7l RCSB], [https://www.ebi.ac.uk/pdbsum/3q7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7l ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the E2 domain of amyloid precursor-like protein 1===
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== Function ==
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[https://www.uniprot.org/uniprot/APLP1_HUMAN APLP1_HUMAN] May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3q7l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7L OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ha, Y.]]
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[[Category: Large Structures]]
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[[Category: Xue, Y.]]
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[[Category: Ha Y]]
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[[Category: Alzheimer's disease]]
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[[Category: Xue Y]]
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[[Category: Aplp1 e2 domain]]
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[[Category: Heparin]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the E2 domain of amyloid precursor-like protein 1

PDB ID 3q7l

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