3zr9
From Proteopedia
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| - | [[Image:3zr9.jpg|left|200px]] | ||
| - | + | ==Structure of New Delhi Metallo-Beta-lactamase 1 (NDM-1)== | |
| - | + | <StructureSection load='3zr9' size='340' side='right'caption='[[3zr9]], [[Resolution|resolution]] 1.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3zr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZR9 FirstGlance]. <br> | |
| - | or | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91Å</td></tr> |
| - | - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr9 OCA], [https://pdbe.org/3zr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zr9 RCSB], [https://www.ebi.ac.uk/pdbsum/3zr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zr9 ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-beta-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1. | ||
| - | + | Structure of New Delhi metallo-beta-lactamase 1 (NDM-1).,Green VL, Verma A, Owens RJ, Phillips SE, Carr SB Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt, 10):1160-4. Epub 2011 Sep 6. PMID:22102018<ref>PMID:22102018</ref> | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 3zr9" style="background-color:#fffaf0;"></div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Klebsiella pneumoniae]] | [[Category: Klebsiella pneumoniae]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Carr SB]] |
| - | [[Category: | + | [[Category: Green VL]] |
| - | [[Category: | + | [[Category: Owens RJ]] |
| - | [[Category: | + | [[Category: Phillips SEV]] |
| - | [[Category: | + | [[Category: Verma A]] |
Current revision
Structure of New Delhi Metallo-Beta-lactamase 1 (NDM-1)
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