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3zr9

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[[Image:3zr9.jpg|left|200px]]
 
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==Structure of New Delhi Metallo-Beta-lactamase 1 (NDM-1)==
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The line below this paragraph, containing "STRUCTURE_3zr9", creates the "Structure Box" on the page.
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<StructureSection load='3zr9' size='340' side='right'caption='[[3zr9]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZR9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3zr9| PDB=3zr9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr9 OCA], [https://pdbe.org/3zr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zr9 RCSB], [https://www.ebi.ac.uk/pdbsum/3zr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zr9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-beta-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1.
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===STRUCTURE OF NEW DELHI METALLO-BETA-LACTAMASE 1 (NDM-1)===
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Structure of New Delhi metallo-beta-lactamase 1 (NDM-1).,Green VL, Verma A, Owens RJ, Phillips SE, Carr SB Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt, 10):1160-4. Epub 2011 Sep 6. PMID:22102018<ref>PMID:22102018</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zr9" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3zr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR9 OCA].
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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[[Category: Beta-lactamase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: Carr, S B.]]
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[[Category: Large Structures]]
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[[Category: Green, V L.]]
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[[Category: Carr SB]]
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[[Category: Owens, R J.]]
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[[Category: Green VL]]
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[[Category: Phillips, S E.V.]]
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[[Category: Owens RJ]]
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[[Category: Verma, A.]]
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[[Category: Phillips SEV]]
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[[Category: Hydrolase]]
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[[Category: Verma A]]

Current revision

Structure of New Delhi Metallo-Beta-lactamase 1 (NDM-1)

PDB ID 3zr9

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