2gjm

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(New page: 200px<br /><applet load="2gjm" size="350" color="white" frame="true" align="right" spinBox="true" caption="2gjm, resolution 2.75&Aring;" /> '''Crystal structure of...)
Current revision (08:04, 30 October 2024) (edit) (undo)
 
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[[Image:2gjm.gif|left|200px]]<br /><applet load="2gjm" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2gjm, resolution 2.75&Aring;" />
 
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'''Crystal structure of Buffalo lactoperoxidase at 2.75A resolution'''<br />
 
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==About this Structure==
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==Crystal structure of Buffalo lactoperoxidase at 2.75A resolution==
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2GJM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis] with <scene name='pdbligand=SCN:'>SCN</scene>, <scene name='pdbligand=CO3:'>CO3</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=IOD:'>IOD</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJM OCA].
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<StructureSection load='2gjm' size='340' side='right'caption='[[2gjm]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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[[Category: Bubalus bubalis]]
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== Structural highlights ==
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[[Category: Peroxidase]]
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<table><tr><td colspan='2'>[[2gjm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJM FirstGlance]. <br>
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[[Category: Protein complex]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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[[Category: Ethayathulla, A.S.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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[[Category: Sharma, S.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjm OCA], [https://pdbe.org/2gjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjm RCSB], [https://www.ebi.ac.uk/pdbsum/2gjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjm ProSAT]</span></td></tr>
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[[Category: Sheikh, I.A.]]
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</table>
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[[Category: Singh, A.K.]]
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== Function ==
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[[Category: Singh, N.]]
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[https://www.uniprot.org/uniprot/PERL_BUBBU PERL_BUBBU] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.<ref>PMID:12071645</ref>
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[[Category: Singh, T.P.]]
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== Evolutionary Conservation ==
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[[Category: CA]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: CO3]]
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Check<jmol>
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[[Category: HEM]]
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<jmolCheckbox>
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[[Category: IOD]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/2gjm_consurf.spt"</scriptWhenChecked>
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[[Category: SCN]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: buffalo]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: crystal structure]]
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</jmolCheckbox>
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[[Category: lactoperoxidase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gjm ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 20:01:20 2008''
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==See Also==
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*[[Lactoperoxidase|Lactoperoxidase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bubalus bubalis]]
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[[Category: Large Structures]]
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[[Category: Ethayathulla AS]]
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[[Category: Sharma S]]
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[[Category: Sheikh IA]]
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[[Category: Singh AK]]
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[[Category: Singh N]]
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[[Category: Singh TP]]

Current revision

Crystal structure of Buffalo lactoperoxidase at 2.75A resolution

PDB ID 2gjm

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