2gku

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(New page: 200px<br /><applet load="2gku" size="350" color="white" frame="true" align="right" spinBox="true" caption="2gku" /> '''Monomeric human telomere DNA tetraplex with ...)
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[[Image:2gku.gif|left|200px]]<br /><applet load="2gku" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2gku" />
 
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'''Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures'''<br />
 
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==Overview==
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==Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures==
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We present the intramolecular G-quadruplex structure of human telomeric, DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3, + 1) topology differs from folds reported previously in Na(+) solution and, in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn, and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two, edgewise loops; three G-tracts oriented in one direction and the fourth in, the opposite direction. The topological characteristics of this (3 + 1), G-quadruplex scaffold should provide a unique platform for structure-based, anticancer drug design targeted to human telomeric DNA.
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<StructureSection load='2gku' size='340' side='right'caption='[[2gku]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GKU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gku OCA], [https://pdbe.org/2gku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gku RCSB], [https://www.ebi.ac.uk/pdbsum/2gku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gku ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.
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==About this Structure==
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Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.,Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556<ref>PMID:16866556</ref>
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2GKU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16866556 16866556]
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</div>
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<div class="pdbe-citations 2gku" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Kuryavyi, V.V.]]
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[[Category: Kuryavyi VV]]
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[[Category: Lacroix, L.]]
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[[Category: Lacroix L]]
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[[Category: Luu, K.N.]]
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[[Category: Luu KN]]
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[[Category: Patel, D.J.]]
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[[Category: Patel DJ]]
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[[Category: Phan, A.T.]]
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[[Category: Phan AT]]
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[[Category: 12 structures]]
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[[Category: double-chain reversal loops; nmr]]
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[[Category: g-tetrad; 3+1 strand folding;edgewise]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 20:02:07 2008''
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Current revision

Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures

PDB ID 2gku

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