3rg9

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[[Image:3rg9.png|left|200px]]
 
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==Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210==
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The line below this paragraph, containing "STRUCTURE_3rg9", creates the "Structure Box" on the page.
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<StructureSection load='3rg9' size='340' side='right'caption='[[3rg9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rg9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RG9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=WRA:6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>WRA</scene></td></tr>
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{{STRUCTURE_3rg9| PDB=3rg9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rg9 OCA], [https://pdbe.org/3rg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rg9 RCSB], [https://www.ebi.ac.uk/pdbsum/3rg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rg9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DRTS_TRYBB DRTS_TRYBB] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
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===Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210===
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_21650210}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21650210 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21650210}}
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==About this Structure==
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[[3rg9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RG9 OCA].
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==Reference==
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<ref group="xtra">PMID:021650210</ref><references group="xtra"/>
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[[Category: Dihydrofolate reductase]]
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[[Category: Trypanosoma brucei rhodesiense]]
[[Category: Trypanosoma brucei rhodesiense]]
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[[Category: Vanichtanankul, J.]]
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[[Category: Vanichtanankul J]]
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[[Category: Yuthavong, Y.]]
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[[Category: Yuthavong Y]]
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[[Category: Yuvaniyama, J.]]
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[[Category: Yuvaniyama J]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Trypanosoma brucei]]
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[[Category: Wr99210]]
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Current revision

Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210

PDB ID 3rg9

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OCA

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