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3si0

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[[Image:3si0.png|left|200px]]
 
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==Structure of glycosylated human glutaminyl cyclase==
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The line below this paragraph, containing "STRUCTURE_3si0", creates the "Structure Box" on the page.
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<StructureSection load='3si0' size='340' side='right'caption='[[3si0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3si0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SI0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3si0| PDB=3si0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3si0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3si0 OCA], [https://pdbe.org/3si0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3si0 RCSB], [https://www.ebi.ac.uk/pdbsum/3si0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3si0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/QPCT_HUMAN QPCT_HUMAN] Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.<ref>PMID:15063747</ref> <ref>PMID:18486145</ref> <ref>PMID:21288892</ref>
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===Structure of glycosylated human glutaminyl cyclase===
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==See Also==
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*[[Glutaminyl cyclase|Glutaminyl cyclase]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21671571 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21671571}}
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==About this Structure==
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[[3si0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SI0 OCA].
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==Reference==
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<ref group="xtra">PMID:021671571</ref><references group="xtra"/>
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[[Category: Glutaminyl-peptide cyclotransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Carillo, D.]]
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[[Category: Large Structures]]
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[[Category: Parthier, C.]]
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[[Category: Carrillo D]]
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[[Category: Stubbs, M T.]]
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[[Category: Parthier C]]
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[[Category: Alpha/beta hydrolase]]
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[[Category: Stubbs MT]]
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[[Category: Alzheimer's disease]]
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[[Category: Glycoprotein]]
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[[Category: Glycosylation]]
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[[Category: Pe]]
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[[Category: Pglu]]
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[[Category: Pglu-amyloid]]
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[[Category: Pyroglutamate]]
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[[Category: Transferase]]
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Current revision

Structure of glycosylated human glutaminyl cyclase

PDB ID 3si0

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