2gop

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(New page: 200px<br /><applet load="2gop" size="350" color="white" frame="true" align="right" spinBox="true" caption="2gop, resolution 2.00&Aring;" /> '''The beta-propeller d...)
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[[Image:2gop.gif|left|200px]]<br /><applet load="2gop" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2gop, resolution 2.00&Aring;" />
 
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'''The beta-propeller domain of the Trilobed protease from Pyrococcus furiosus reveals an open velcro topology'''<br />
 
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==Overview==
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==The beta-propeller domain of the Trilobed protease from Pyrococcus furiosus reveals an open velcro topology==
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In the proteolytic pathway of prokaryotic and eukaryotic organisms, proteins tagged for proteolysis are firstly shredded into smaller peptides, by compartmentalized proteases such as the proteasome complex., Accordingly, a variety of downstream proteases have evolved to further, hydrolyze these peptides to the level of free amino acids. In the search, for such downstream proteases, a high-molecular-weight protease complex, called trilobed protease (TLP) was recently discovered in the archaeon, Pyroccocus furiosus. The crystal structure of the N-terminal, beta-propeller domain of the trilobed protease at 2 A resolution shows, that the trilobed protease utilizes this accessory domain to control, substrate access to the active site. Modelling of the intact TLP monomer, suggests that this protease has an additional side entrance to its active, site as in the DPP-IV or tricorn protease complexes.
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<StructureSection load='2gop' size='340' side='right'caption='[[2gop]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2gop]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOP FirstGlance]. <br>
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2GOP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOP OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gop OCA], [https://pdbe.org/2gop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gop RCSB], [https://www.ebi.ac.uk/pdbsum/2gop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gop ProSAT]</span></td></tr>
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==Reference==
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</table>
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The beta-propeller domain of the trilobed protease from Pyrococcus furiosus reveals an open Velcro topology., Bosch J, Tamura T, Tamura N, Baumeister W, Essen LO, Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):179-87. Epub 2007, Jan 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17242511 17242511]
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== Function ==
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[https://www.uniprot.org/uniprot/Q8U3Y3_PYRFU Q8U3Y3_PYRFU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/2gop_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gop ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Single protein]]
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[[Category: Baumeister W]]
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[[Category: Baumeister, W.]]
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[[Category: Bosch J]]
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[[Category: Bosch, J.]]
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[[Category: Essen L-O]]
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[[Category: Essen, L.O.]]
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[[Category: Tamura N]]
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[[Category: Tamura, N.]]
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[[Category: Tamura T]]
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[[Category: Tamura, T.]]
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[[Category: beta propeller]]
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[[Category: open velcro]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 20:04:42 2008''
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Current revision

The beta-propeller domain of the Trilobed protease from Pyrococcus furiosus reveals an open velcro topology

PDB ID 2gop

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