3s57

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'''Unreleased structure'''
 
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The entry 3s57 is ON HOLD until Paper Publication
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==ABH2 cross-linked with undamaged dsDNA-1 containing cofactors==
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<StructureSection load='3s57' size='340' side='right'caption='[[3s57]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3s57]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S57 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XL3:PROPANE-1-THIOL'>XL3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s57 OCA], [https://pdbe.org/3s57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s57 RCSB], [https://www.ebi.ac.uk/pdbsum/3s57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s57 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref>
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Authors: Yi, C., Chen, B., Qi, B., Ramirez, B., Zhang, W., Jia, G., Zhang, L., Li, C.Q., Dinner, A.R., Yang, C.-G., He, C.
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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Description: ABH2 cross-linked with undamaged dsDNA-1 containing cofactors
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen B]]
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[[Category: Dinner AR]]
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[[Category: He C]]
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[[Category: Jia G]]
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[[Category: Li CQ]]
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[[Category: Qi B]]
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[[Category: Ramirez B]]
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[[Category: Yang C-G]]
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[[Category: Yi C]]
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[[Category: Zhang L]]
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[[Category: Zhang W]]

Current revision

ABH2 cross-linked with undamaged dsDNA-1 containing cofactors

PDB ID 3s57

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OCA

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