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3smr

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'''Unreleased structure'''
 
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The entry 3smr is ON HOLD
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==Crystal structure of human WD repeat domain 5 with compound==
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<StructureSection load='3smr' size='340' side='right'caption='[[3smr]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3smr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SMR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NP7:2-CHLORO-N-[2-(4-METHYLPIPERAZIN-1-YL)-5-NITROPHENYL]BENZAMIDE'>NP7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3smr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smr OCA], [https://pdbe.org/3smr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3smr RCSB], [https://www.ebi.ac.uk/pdbsum/3smr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3smr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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Authors: DONG,A., Dombrovski,L., Wasney,G.A., TEMPEL,W., Senisterra,G., Bolshan,Y., Smil,D., Nguyen,K.T., Hajian,T., Poda,G., Al-Awar,R., Bountra,C., Weigelt,J., Edwards,A.M., Brown,P.J., Schapira,M., Arrowsmith,C.H., Vedadi,M., WU,H., Structural Genomics Consortium (SGC)
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
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Description: Crystal structure of human WD repeat domain 5 with compound
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Al-Awar R]]
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[[Category: Arrowsmith CH]]
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[[Category: Bolshan Y]]
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[[Category: Bountra C]]
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[[Category: Brown PJ]]
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[[Category: Dombrovski L]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Hajian T]]
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[[Category: Nguyen KT]]
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[[Category: Poda G]]
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[[Category: Schapira M]]
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[[Category: Senisterra G]]
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[[Category: Smil D]]
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[[Category: Tempel W]]
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[[Category: Vedadi M]]
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[[Category: Wasney GA]]
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[[Category: Weigelt J]]
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[[Category: Wu H]]

Current revision

Crystal structure of human WD repeat domain 5 with compound

PDB ID 3smr

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OCA

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