3sn5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3sn5 is ON HOLD Authors: Strushkevich, N., Tempel, W., MacKenzie, F., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Pa...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one== | |
| + | <StructureSection load='3sn5' size='340' side='right'caption='[[3sn5]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3sn5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SN5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K2B:(8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE'>K2B</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sn5 OCA], [https://pdbe.org/3sn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sn5 RCSB], [https://www.ebi.ac.uk/pdbsum/3sn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sn5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CP7A1_HUMAN CP7A1_HUMAN] Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.<ref>PMID:19965590</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: MacKenzie F]] | ||
| + | [[Category: Park H]] | ||
| + | [[Category: Strushkevich N]] | ||
| + | [[Category: Tempel W]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Wernimont AK]] | ||
Current revision
Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one
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