3sni

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(New page: '''Unreleased structure''' The entry 3sni is ON HOLD Authors: Malamas, M. S., Ni, Y., Erdei, J., Stange, H., Schindler, R., Lankau, H.-J., Grunwald, C., Fan, K. Y., Parris, K. D., Lange...)
Current revision (09:52, 1 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3sni is ON HOLD
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==Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors==
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<StructureSection load='3sni' size='340' side='right'caption='[[3sni]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SNI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=546:2-METHOXY-6,7-DIMETHYL-9-(4-METHYLPYRIDIN-3-YL)IMIDAZO[1,5-A]PYRIDO[3,2-E]PYRAZINE'>546</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sni OCA], [https://pdbe.org/3sni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sni RCSB], [https://www.ebi.ac.uk/pdbsum/3sni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sni ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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Authors: Malamas, M. S., Ni, Y., Erdei, J., Stange, H., Schindler, R., Lankau, H.-J., Grunwald, C., Fan, K. Y., Parris, K. D., Langen, B., Egerland, U., Hage, T., Marquis, K. L., Grauer, S., Brennan, J., Navarra, R., Graf, R., Harrison, B. L., Robichaud, A., Kronbach, T., Pangalos, M., Hofgen, N., Brandon, N. J.
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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Description: Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Brandon NJ]]
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[[Category: Brennan J]]
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[[Category: Egerland U]]
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[[Category: Erdei J]]
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[[Category: Fan KY]]
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[[Category: Graf R]]
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[[Category: Grauer S]]
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[[Category: Grunwald C]]
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[[Category: Hage T]]
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[[Category: Harrison BL]]
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[[Category: Hofgen N]]
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[[Category: Kronbach T]]
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[[Category: Langen B]]
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[[Category: Lankau H-J]]
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[[Category: Malamas MS]]
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[[Category: Marquis KL]]
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[[Category: Navarra R]]
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[[Category: Ni Y]]
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[[Category: Pangalos M]]
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[[Category: Parris KD]]
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[[Category: Robichaud A]]
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[[Category: Schindler R]]
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[[Category: Stange H]]

Current revision

Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors

PDB ID 3sni

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