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3soc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin== | |
| - | + | <StructureSection load='3soc' size='340' side='right'caption='[[3soc]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3soc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SOC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GVD:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE'>GVD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3soc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3soc OCA], [https://pdbe.org/3soc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3soc RCSB], [https://www.ebi.ac.uk/pdbsum/3soc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3soc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Bullock A]] | ||
| + | [[Category: Chaikuad A]] | ||
| + | [[Category: Cooper CDO]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Mahajan P]] | ||
| + | [[Category: Muniz JRC]] | ||
| + | [[Category: Sanvitale C]] | ||
| + | [[Category: Vollmar M]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Williams E]] | ||
| + | [[Category: Yue WW]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Bullock A | Chaikuad A | Cooper CDO | Edwards AM | Mahajan P | Muniz JRC | Sanvitale C | Vollmar M | Weigelt J | Williams E | Yue WW | Von Delft F
