2lda

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[[Image:2lda.jpg|left|200px]]
 
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==Solution structure of the estrogen receptor-binding stapled peptide SP2 (Ac-HKXLHQXLQDS-NH2)==
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The line below this paragraph, containing "STRUCTURE_2lda", creates the "Structure Box" on the page.
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<StructureSection load='2lda' size='340' side='right'caption='[[2lda]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lda]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LDA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_2lda| PDB=2lda | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lda OCA], [https://pdbe.org/2lda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lda RCSB], [https://www.ebi.ac.uk/pdbsum/2lda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lda ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Synthetic peptides that specifically bind nuclear hormone receptors offer an alternative approach to small molecules for the modulation of receptor signaling and subsequent gene expression. Here we describe the design of a series of novel stapled peptides that bind the coactivator peptide site of estrogen receptors. Using a number of biophysical techniques, including crystal structure analysis of receptor-stapled peptide complexes, we describe in detail the molecular interactions and demonstrate that all-hydrocarbon staples modulate molecular recognition events. The findings have implications for the design of stapled peptides in general.
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===Solution structure of the estrogen receptor-binding stapled peptide SP2 (Ac-HKXLHQXLQDS-NH2)===
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Design and structure of stapled peptides binding to estrogen receptors.,Phillips C, Roberts LR, Schade M, Bazin R, Bent A, Davies NL, Moore R, Pannifer AD, Pickford AR, Prior SH, Read CM, Scott A, Brown DG, Xu B, Irving SL J Am Chem Soc. 2011 Jun 29;133(25):9696-9. Epub 2011 Jun 6. PMID:21612236<ref>PMID:21612236</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21612236}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2lda" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21612236 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21612236}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2lda]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LDA OCA].
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[[Category: Bazin R]]
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[[Category: Bent A]]
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==Reference==
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[[Category: Brown D]]
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<ref group="xtra">PMID:021612236</ref><references group="xtra"/>
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[[Category: Davies N]]
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[[Category: Bazin, R.]]
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[[Category: Irving S]]
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[[Category: Bent, A.]]
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[[Category: Moore R]]
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[[Category: Brown, D.]]
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[[Category: Pannifer A]]
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[[Category: Davies, N.]]
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[[Category: Phillips C]]
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[[Category: Irving, S.]]
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[[Category: Pickford A]]
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[[Category: Moore, R.]]
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[[Category: Prior S]]
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[[Category: Pannifer, A.]]
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[[Category: Read C]]
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[[Category: Phillips, C.]]
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[[Category: Roberts L]]
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[[Category: Pickford, A.]]
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[[Category: Schade M]]
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[[Category: Prior, S.]]
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[[Category: Scott A]]
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[[Category: Read, C.]]
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[[Category: Xu B]]
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[[Category: Roberts, L.]]
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[[Category: Schade, M.]]
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[[Category: Scott, A.]]
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[[Category: Xu, B.]]
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[[Category: De novo protein]]
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Current revision

Solution structure of the estrogen receptor-binding stapled peptide SP2 (Ac-HKXLHQXLQDS-NH2)

PDB ID 2lda

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