3od4

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[[Image:3od4.jpg|left|200px]]
 
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==Crystal Structure of Factor Inhibiting HIF-1 Alpha Complexed with Inhibitor==
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The line below this paragraph, containing "STRUCTURE_3od4", creates the "Structure Box" on the page.
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<StructureSection load='3od4' size='340' side='right'caption='[[3od4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3od4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OD4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8XQ:8-HYDROXYQUINOLINE-5-CARBOXYLIC+ACID'>8XQ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3od4| PDB=3od4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3od4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3od4 OCA], [https://pdbe.org/3od4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3od4 RCSB], [https://www.ebi.ac.uk/pdbsum/3od4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3od4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HIF1N_HUMAN HIF1N_HUMAN] Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.<ref>PMID:12080085</ref> <ref>PMID:12042299</ref> <ref>PMID:17003112</ref> <ref>PMID:18299578</ref> <ref>PMID:19245366</ref> <ref>PMID:17573339</ref> <ref>PMID:21251231</ref> <ref>PMID:21177872</ref>
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===Crystal Structure of Factor Inhibiting HIF-1 Alpha Complexed with Inhibitor===
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==See Also==
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*[[Factor inhibiting HIF|Factor inhibiting HIF]]
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*[[Hypoxia-Inducible factor 1 alpha inhibitor|Hypoxia-Inducible factor 1 alpha inhibitor]]
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==About this Structure==
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== References ==
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[[3od4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OD4 OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptide-aspartate beta-dioxygenase]]
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[[Category: Large Structures]]
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[[Category: Bashford-Rogers, R.]]
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[[Category: Bashford-Rogers R]]
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[[Category: Clifton, I J.]]
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[[Category: Clifton IJ]]
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[[Category: Heightman, T D.]]
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[[Category: Heightman TD]]
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[[Category: Jadhav, A.]]
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[[Category: Jadhav A]]
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[[Category: King, O N.F.]]
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[[Category: King ONF]]
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[[Category: Maloney, D J.]]
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[[Category: Maloney DJ]]
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[[Category: McDonough, M A.]]
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[[Category: McDonough MA]]
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[[Category: Schofield, C J.]]
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[[Category: Schofield CJ]]
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[[Category: Simeonov, A.]]
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[[Category: Simeonov A]]
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[[Category: Asparaginyl hydroxylase]]
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[[Category: Dioxygenase]]
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[[Category: Hif]]
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[[Category: Hydroxylation]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Oxygenase]]
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[[Category: Transcription]]
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Current revision

Crystal Structure of Factor Inhibiting HIF-1 Alpha Complexed with Inhibitor

PDB ID 3od4

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