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Hormone
From Proteopedia
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In the field of modern endocrinology, a [[Hormone|hormone]] is any substance, generated either externally or internally, that operates via a receptor at the cellular level, which conveys to to the cell a message to stop, start, or modulate a cellular process. | In the field of modern endocrinology, a [[Hormone|hormone]] is any substance, generated either externally or internally, that operates via a receptor at the cellular level, which conveys to to the cell a message to stop, start, or modulate a cellular process. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
| - | ==Guide to Proteopedia Pages Concerning Hormones and Receptors== | + | ==Guide to Proteopedia Pages Concerning Hormones and their Receptors== |
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{{#tree:id=HormoneTopic|openlevels=0| | {{#tree:id=HormoneTopic|openlevels=0| | ||
Articles in Proteopedia concerning [[Hormone]] include: | Articles in Proteopedia concerning [[Hormone]] include: | ||
| + | <!--* [[Follicle-stimulating hormone]] --> | ||
| + | * [[Hormones and their receptors]] | ||
| + | * [[Steroid Hormones and their receptors]] | ||
| + | * [[Signal transduction]] | ||
| + | * [[Sex steroids]] | ||
| + | * [[Steroids]] | ||
* [[Human Follicle-Stimulating Hormone Complexed with its Receptor]] | * [[Human Follicle-Stimulating Hormone Complexed with its Receptor]] | ||
| + | * [[Estrogen receptor]] | ||
| + | * [[Estrogen-related receptor]] | ||
| + | * [[Androgen receptor|Androgen Receptor]] | ||
* [[Leucine-rich repeat|Leucine-rich repeat proteins]] | * [[Leucine-rich repeat|Leucine-rich repeat proteins]] | ||
| + | * [[Human growth hormone]] | ||
* [[Vascular Endothelial Growth Factor]] | * [[Vascular Endothelial Growth Factor]] | ||
* [[Vascular Endothelial Growth Factor Receptor]] | * [[Vascular Endothelial Growth Factor Receptor]] | ||
| - | + | * [[Receiver domain of sensor histidine kinase CKI1]] | |
| + | * [[Beta-2 Adrenergic Receptor]] | ||
| + | * [[Journal:JBSD:2|Neurotensin]] | ||
| + | * [[Neurotensin receptor]] | ||
| + | * [[Glucagon]] | ||
| + | * [[Glucagon receptor]] | ||
| + | * [[Hormone sensitive lipase]] | ||
| + | * [[Corticosteroid-binding globulin]] | ||
| + | * [[Erythropoietin]] | ||
| + | * [[Erythropoietin receptor]] | ||
| + | * [[Thyroid hormone receptor]] | ||
}} | }} | ||
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==Additional 3D Structures of Hormones and Hormone Receptors and Related Molecules== | ==Additional 3D Structures of Hormones and Hormone Receptors and Related Molecules== | ||
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| + | ===Adrenaline=== | ||
| + | [[Image:7tm labeled.png|right|400px]] | ||
| + | [[Beta-2 Adrenergic Receptor]]<br /> | ||
| + | The human β2 adrenergic receptor bound to a [[hormone]] analog and G-protein ([[3sn6]]) is featured in an image on the right, and additional structures are on the [[Adrenergic receptor|Adrenergic receptor page]]. <br /> | ||
| + | {{Template:GPCR3sn6}} | ||
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===Angiotensinogen=== | ===Angiotensinogen=== | ||
| - | [[ | + | [[Serpin]] |
===Chorionic Gonadotropin=== | ===Chorionic Gonadotropin=== | ||
| - | [[1hrp]] - | + | |
| - | [[ | + | [[1hrp]], [[1hcn]] - hCG – human<br /> |
| - | [[ | + | [[1hd4]] - α-subunit of hCG <br /> |
| + | [[1e9j]], [[1dz7]] - α-subunit of hCG - NMR<br /> | ||
| + | [[1qfw]] - hCG + antibody<br /> | ||
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| + | === Estrogen receptor === | ||
| + | [[Estrogen receptor]] | ||
| + | |||
| + | ===Estrogen-related Receptor=== | ||
| + | [[Estrogen-related receptor]] | ||
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| + | ===Androgen Receptor=== | ||
| + | [[Androgen receptor|Nuclear Androgen Receptor]] | ||
===Follicle-Stimulating Hormone=== | ===Follicle-Stimulating Hormone=== | ||
| - | [[ | + | [[Follicle-stimulating hormone]] |
| - | [[ | + | |
| + | ===PACAP/glucagon family of peptide hormones=== | ||
| + | [[3n94]] - PAC1R, receptor of pituitary adenylate cyclase activating polypeptide, is a case of a crystal structure disagreeing with the NMR structure [[2jod]] and vice versa <br /> | ||
| + | [[2jod]] - Pituitary adenylate cyclase-activating polypeptide (residues 6'-38') complexed to the extracellular | ||
===Glucocorticoid=== | ===Glucocorticoid=== | ||
| - | [[ | + | [[Glucocorticoid receptor]] |
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| + | ===Glucose-dependent Insulinotropic Polypeptide=== | ||
| + | [[Glucose-dependent Insulinotropic Polypeptide Receptor]] | ||
===Growth Hormone=== | ===Growth Hormone=== | ||
| - | [[ | + | [[Human growth hormone]] is featured [[Human growth hormone|here]].<br /> |
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===Insulin=== | ===Insulin=== | ||
| - | [[ | + | [[Insulin]] |
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| - | === | + | ===Progesterone === |
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| - | + | [[1a28]] - hProgR steroid-binding domain + progesterone<br /> | |
| - | [[ | + | |
==See Also== | ==See Also== | ||
* [[Cancer]] | * [[Cancer]] | ||
| + | * [[Membrane proteins]] | ||
| + | * [[G protein-coupled receptor|G protein-coupled receptors]] | ||
| + | * [[Nobel Prizes for 3D Molecular Structure]] | ||
| + | * [[Highest impact structures]] of all time | ||
| + | * [[Hormones and their receptors]] | ||
==External Resources== | ==External Resources== | ||
* [http://www.ssfa-gphr.de/index.php Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors] | * [http://www.ssfa-gphr.de/index.php Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors] | ||
| + | * [http://gris.ulb.ac.be/ GRIS: Glycoprotein-hormone Receptors Information System] | ||
* [http://www.ssfa-7tmr.de/ssfe/ The GPCR-SSFE Database: A Homology Model Resource for G-Protein Coupled Receptors] | * [http://www.ssfa-7tmr.de/ssfe/ The GPCR-SSFE Database: A Homology Model Resource for G-Protein Coupled Receptors] | ||
* The [http://www.rcsb.org/pdb/101/motm.do?momID=52 feature on Growth Hormone] by Shuchismita Dutta and David S. Goodsell for the April 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. | * The [http://www.rcsb.org/pdb/101/motm.do?momID=52 feature on Growth Hormone] by Shuchismita Dutta and David S. Goodsell for the April 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. | ||
| + | * [http://proteomics.ucsd.edu/Software/NeuroPedia.html NeuroPedia, a neuropeptide database and spectral library] | ||
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[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Signaling]] | [[Category:Signaling]] | ||
| + | [[Category:Cystine-knot growth factor|Cystine-knot growth factor]] | ||
| + | [[Category:Cyclic cystine knot|Cyclic cystine knot]] | ||
| + | [[Category:Cystine knot superfamily|Cystine knot superfamily]] | ||
| + | [[Category:Cystine knot motif|Cystine knot motif]] | ||
Current revision
In the field of modern endocrinology, a hormone is any substance, generated either externally or internally, that operates via a receptor at the cellular level, which conveys to to the cell a message to stop, start, or modulate a cellular process.
Guide to Proteopedia Pages Concerning Hormones and their Receptors
Articles in Proteopedia concerning Hormone include:
To view automatically seeded indices concerning Hormone, see:
Additional 3D Structures of Hormones and Hormone Receptors and Related Molecules
Adrenaline
Beta-2 Adrenergic Receptor
The human β2 adrenergic receptor bound to a hormone analog and G-protein (3sn6) is featured in an image on the right, and additional structures are on the Adrenergic receptor page.
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Angiotensinogen
Chorionic Gonadotropin
1hrp, 1hcn - hCG – human
1hd4 - α-subunit of hCG
1e9j, 1dz7 - α-subunit of hCG - NMR
1qfw - hCG + antibody
Estrogen receptor
Estrogen-related Receptor
Androgen Receptor
Follicle-Stimulating Hormone
PACAP/glucagon family of peptide hormones
3n94 - PAC1R, receptor of pituitary adenylate cyclase activating polypeptide, is a case of a crystal structure disagreeing with the NMR structure 2jod and vice versa
2jod - Pituitary adenylate cyclase-activating polypeptide (residues 6'-38') complexed to the extracellular
Glucocorticoid
Glucose-dependent Insulinotropic Polypeptide
Glucose-dependent Insulinotropic Polypeptide Receptor
Growth Hormone
Human growth hormone is featured here.
Insulin
Progesterone
1a28 - hProgR steroid-binding domain + progesterone
See Also
- Cancer
- Membrane proteins
- G protein-coupled receptors
- Nobel Prizes for 3D Molecular Structure
- Highest impact structures of all time
- Hormones and their receptors
External Resources
- Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors
- GRIS: Glycoprotein-hormone Receptors Information System
- The GPCR-SSFE Database: A Homology Model Resource for G-Protein Coupled Receptors
- The feature on Growth Hormone by Shuchismita Dutta and David S. Goodsell for the April 2004 RCSB PDB Molecule of the Month.
- NeuroPedia, a neuropeptide database and spectral library
Proteopedia Page Contributors and Editors (what is this?)
Wayne Decatur, Alexander Berchansky, Michal Harel, Tomas Klumpler, Joel L. Sussman
