3sk2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of phenazine resistance protein EhpR from Enterobacter agglomerans (Erwinia herbicola, Pantoea agglomerans) Eh1087 in complex with griseoluteic acid== | |
| - | + | <StructureSection load='3sk2' size='340' side='right'caption='[[3sk2]], [[Resolution|resolution]] 1.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3sk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pantoea_agglomerans Pantoea agglomerans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SK2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.01Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GRI:6-FORMYL-9-METHOXYPHENAZINE-1-CARBOXYLIC+ACID'>GRI</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sk2 OCA], [https://pdbe.org/3sk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sk2 RCSB], [https://www.ebi.ac.uk/pdbsum/3sk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sk2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EHPR_ENTAG EHPR_ENTAG] Required for resistance to the phenazine antibiotic D-alanylgriseoluteic acid (AGA), an antibiotic produced by E.agglomerans itself, and thus protects the bacterium against phenazine toxicity. Probably binds AGA and acts as a chaperone that works in tandem with a membrane transporter for subsequent antibiotic secretion.<ref>PMID:12139622</ref> <ref>PMID:21849072</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pantoea agglomerans]] | ||
| + | [[Category: Blankenfeldt W]] | ||
| + | [[Category: Yu S]] | ||
Current revision
Crystal structure of phenazine resistance protein EhpR from Enterobacter agglomerans (Erwinia herbicola, Pantoea agglomerans) Eh1087 in complex with griseoluteic acid
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