3sr4

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m (Protected "3sr4" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 3sr4 is ON HOLD
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==Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor==
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<StructureSection load='3sr4' size='340' side='right'caption='[[3sr4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SR4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TT8:(2S)-2-AZANYL-4-[[(2S,3S,4R,5R)-5-[6-(METHYLAMINO)PURIN-9-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYLSULFANYL]BUTANOIC+ACID'>TT8</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sr4 OCA], [https://pdbe.org/3sr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sr4 RCSB], [https://www.ebi.ac.uk/pdbsum/3sr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sr4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
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Authors: Diao, J., Chen, P., Yao, Y., Prasad, B.V.V., Song, Y.
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: Crystal structure of a DOT1:inhibitor complex
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen P]]
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[[Category: Diao J]]
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[[Category: Prasad BVV]]
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[[Category: Song Y]]
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[[Category: Yao Y]]

Current revision

Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor

PDB ID 3sr4

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