3pgb

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[[Image:3pgb.jpg|left|200px]]
 
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==Crystal structure of Aspergillus nidulans amine oxidase==
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The line below this paragraph, containing "STRUCTURE_3pgb", creates the "Structure Box" on the page.
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<StructureSection load='3pgb' size='340' side='right'caption='[[3pgb]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pgb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_nidulans Aspergillus nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PGB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TPQ:5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE'>TPQ</scene></td></tr>
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{{STRUCTURE_3pgb| PDB=3pgb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgb OCA], [https://pdbe.org/3pgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pgb RCSB], [https://www.ebi.ac.uk/pdbsum/3pgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5B038_EMENI Q5B038_EMENI]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Aspergillus nidulans amine oxidase (ANAO) has the unusual ability among the family of copper and trihydroxyphenylalanine quinone-containing amine oxidases of being able to oxidize the amine side chains of lysine residues in large peptides and proteins. We show here that in common with the related enzyme from the yeast Pichia pastoris, ANAO can promote the cross-linking of tropoelastin and oxidize the lysine residues in alpha-casein proteins and tropoelastin. The crystal structure of ANAO, the first for a fungal enzyme in this family, has been determined to a resolution of 2.4 A. The enzyme is a dimer with the archetypal fold of a copper-containing amine oxidase. The active site is the most open of any of those of the structurally characterized enzymes in the family and provides a ready explanation for its lysine oxidase-like activity.
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===Crystal structure of Aspergillus nidulans amine oxidase===
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Structure and Activity of Aspergillus nidulans Copper Amine Oxidase.,McGrath AP, Mithieux SM, Collyer CA, Bakhuis JG, van den Berg M, Sein A, Heinz A, Schmelzer C, Weiss AS, Guss JM Biochemistry. 2011 Jun 28;50(25):5718-30. Epub 2011 Jun 3. PMID:21604787<ref>PMID:21604787</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pgb" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21604787 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21604787}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Aspergillus nidulans]]
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[[3pgb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Emericella_nidulans Emericella nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGB OCA].
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[[Category: Large Structures]]
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[[Category: Guss JM]]
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==Reference==
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[[Category: McGrath AP]]
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<ref group="xtra">PMID:021604787</ref><references group="xtra"/>
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[[Category: Emericella nidulans]]
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[[Category: Oxidoreductase]]
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[[Category: Guss, J M.]]
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[[Category: McGrath, A P.]]
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[[Category: Cao]]
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[[Category: Copper amine oxidase]]
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[[Category: Oxidoreductase]]
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[[Category: Topaquinone]]
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[[Category: Tpq]]
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Current revision

Crystal structure of Aspergillus nidulans amine oxidase

PDB ID 3pgb

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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