2kg7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2kg7" [edit=sysop:move=sysop])
Current revision (06:45, 1 May 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2kg7.png|left|200px]]
 
-
<!--
+
==Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288==
-
The line below this paragraph, containing "STRUCTURE_2kg7", creates the "Structure Box" on the page.
+
<StructureSection load='2kg7' size='340' side='right'caption='[[2kg7]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2kg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KG7 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg7 OCA], [https://pdbe.org/2kg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg7 ProSAT]</span></td></tr>
-
{{STRUCTURE_2kg7| PDB=2kg7 | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288===
+
[https://www.uniprot.org/uniprot/ESXG_MYCTU ESXG_MYCTU] EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol.<ref>PMID:24204276</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==About this Structure==
+
Check<jmol>
-
[[2kg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG7 OCA].
+
<jmolCheckbox>
-
[[Category: Mycobacterium tuberculosis]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kg7_consurf.spt"</scriptWhenChecked>
-
[[Category: Carr, M D.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Ilghari, D.]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: Kirsty, L L.]]
+
</jmolCheckbox>
-
[[Category: Philip, R S.]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kg7 ConSurf].
-
[[Category: Veverka, V L.]]
+
<div style="clear:both"></div>
-
[[Category: Waters, L C.]]
+
== References ==
-
[[Category: Protein complex]]
+
<references/>
-
[[Category: Unknown function]]
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Mycobacterium tuberculosis H37Rv]]
 +
[[Category: Carr MD]]
 +
[[Category: Ilghari D]]
 +
[[Category: Kirsty LL]]
 +
[[Category: Philip RS]]
 +
[[Category: Veverka VL]]
 +
[[Category: Waters LC]]

Current revision

Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288

PDB ID 2kg7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2kg7"
Personal tools