2wbh

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[[Image:2wbh.png|left|200px]]
 
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==Icosahedral particle of covalent coat protein dimer of bacteriophage MS2==
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The line below this paragraph, containing "STRUCTURE_2wbh", creates the "Structure Box" on the page.
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<StructureSection load='2wbh' size='340' side='right'caption='[[2wbh]], [[Resolution|resolution]] 4.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wbh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_MS2 Escherichia virus MS2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbh OCA], [https://pdbe.org/2wbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbh RCSB], [https://www.ebi.ac.uk/pdbsum/2wbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbh ProSAT]</span></td></tr>
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{{STRUCTURE_2wbh| PDB=2wbh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_BPMS2 CAPSD_BPMS2] Self-assembles to form the T=3 icosahedral virus shell that protects the viral nucleic acid. Acts as a translational repressor by binding with high specificity to a single stem-loop structure in the genomic RNA that contains the initiation codon of the gene for the viral replicase. Involved in virus assembly through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome.<ref>PMID:16531233</ref> <ref>PMID:18662904</ref> <ref>PMID:26608810</ref> <ref>PMID:8254664</ref> <ref>PMID:9245600</ref> <ref>PMID:9469847</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Particles formed by the bacteriophage MS2 coat protein mutants with insertions in their surface loops induce a strong immune response against the inserted epitopes. The covalent dimers created by fusion of two copies of the coat protein gene are more tolerant to various insertions into the surface loops than the single subunits. We determined a 4.7-A resolution crystal structure of an icosahedral particle assembled from covalent dimers and compared its stability with wild-type virions. The structure resembled the wild-type virion except for the intersubunit linker regions. The covalent dimer orientation was random with respect to both icosahedral twofold and quasi-twofold symmetry axes. A fraction of the particles was unstable in phosphate buffer because of assembly defects. Our results provide a structural background for design of modified covalent coat protein dimer subunits for use in immunization.
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===ICOSAHEDRAL PARTICLE OF COVALENT COAT PROTEIN DIMER OF BACTERIOPHAGE MS2===
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Structure and stability of icosahedral particles of a covalent coat protein dimer of bacteriophage MS2.,Plevka P, Tars K, Liljas L Protein Sci. 2009 Aug;18(8):1653-61. PMID:19521994<ref>PMID:19521994</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19521994}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wbh" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19521994 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19521994}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia virus MS2]]
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[[2wbh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_ms2 Enterobacteria phage ms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBH OCA].
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[[Category: Large Structures]]
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[[Category: Liljas L]]
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==Reference==
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[[Category: Plevka P]]
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<ref group="xtra">PMID:019521994</ref><references group="xtra"/>
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[[Category: Tars K]]
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[[Category: Enterobacteria phage ms2]]
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[[Category: Liljas, L.]]
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[[Category: Plevka, P.]]
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[[Category: Tars, K.]]
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[[Category: Capsid protein]]
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[[Category: Covalent dimer]]
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[[Category: Rna-binding]]
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[[Category: Virion]]
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[[Category: Virus]]
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Current revision

Icosahedral particle of covalent coat protein dimer of bacteriophage MS2

PDB ID 2wbh

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