2wwa

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[[Image:2wwa.png|left|200px]]
 
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==Cryo-EM structure of idle yeast Ssh1 complex bound to the yeast 80S ribosome==
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The line below this paragraph, containing "STRUCTURE_2wwa", creates the "Structure Box" on the page.
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<SX load='2wwa' size='340' side='right' viewer='molstar' caption='[[2wwa]], [[Resolution|resolution]] 8.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wwa]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WWA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wwa OCA], [https://pdbe.org/2wwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wwa RCSB], [https://www.ebi.ac.uk/pdbsum/2wwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wwa ProSAT]</span></td></tr>
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{{STRUCTURE_2wwa| PDB=2wwa | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SSH1_YEAST SSH1_YEAST] Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2wwa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wwa ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. Although Sec complexes can form oligomers, it has been suggested that a single copy may serve as an active PCC. We determined subnanometer-resolution cryo-electron microscopy structures of eukaryotic ribosome-Sec61 complexes. In combination with biochemical data, we found that in both idle and active states, the Sec complex is not oligomeric and interacts mainly via two cytoplasmic loops with the universal ribosomal adaptor site. In the active state, the ribosomal tunnel and a central pore of the monomeric PCC were occupied by the nascent chain, contacting loop 6 of the Sec complex. This provides a structural basis for the activity of a solitary Sec complex in cotranslational protein translocation.
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===CRYO-EM STRUCTURE OF IDLE YEAST SSH1 COMPLEX BOUND TO THE YEAST 80S RIBOSOME===
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Structure of monomeric yeast and Mammalian sec61 complexes interacting with the translating ribosome.,Becker T, Bhushan S, Jarasch A, Armache JP, Funes S, Jossinet F, Gumbart J, Mielke T, Berninghausen O, Schulten K, Westhof E, Gilmore R, Mandon EC, Beckmann R Science. 2009 Dec 4;326(5958):1369-73. Epub 2009 Oct 29. PMID:19933108<ref>PMID:19933108</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19933108}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wwa" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19933108 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19933108}}
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==About this Structure==
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[[2wwa]] is a 15 chain structure of [[Ribosomal protein L17]], [[Ribosomal protein L23]], [[Ribosomal protein L25]], [[Ribosomal protein L26]], [[Ribosomal protein L31]], [[Ribosomal protein L35]], [[Ribosomal protein L39]] and [[Ribosomal protein L4]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWA OCA].
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==See Also==
==See Also==
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*[[Ribosomal protein L17]]
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*[[Ribosomal protein L17|Ribosomal protein L17]]
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*[[Ribosomal protein L23]]
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*[[Ribosomal protein L19|Ribosomal protein L19]]
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*[[Ribosomal protein L25]]
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*[[Ribosomal protein L23|Ribosomal protein L23]]
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*[[Ribosomal protein L26]]
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*[[Ribosomal protein L25|Ribosomal protein L25]]
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*[[Ribosomal protein L31]]
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*[[Ribosomal protein L26|Ribosomal protein L26]]
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*[[Ribosomal protein L35]]
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*[[Ribosomal protein L31|Ribosomal protein L31]]
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*[[Ribosomal protein L39]]
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*[[Ribosomal protein L35|Ribosomal protein L35]]
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*[[Ribosomal protein L4]]
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*[[Ribosomal protein L39|Ribosomal protein L39]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019933108</ref><references group="xtra"/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Armache, J P.]]
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[[Category: Armache JP]]
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[[Category: Becker, T.]]
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[[Category: Becker T]]
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[[Category: Beckmann, R.]]
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[[Category: Beckmann R]]
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[[Category: Berninghausen, O.]]
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[[Category: Berninghausen O]]
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[[Category: Bhushan, S.]]
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[[Category: Bhushan S]]
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[[Category: Funes, S.]]
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[[Category: Funes S]]
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[[Category: Gilmore, R.]]
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[[Category: Gilmore R]]
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[[Category: Gumbart, J.]]
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[[Category: Gumbart J]]
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[[Category: Jarasch, A.]]
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[[Category: Jarasch A]]
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[[Category: Jossinet, F.]]
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[[Category: Jossinet F]]
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[[Category: Mandon, E.]]
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[[Category: Mandon E]]
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[[Category: Mielke, T.]]
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[[Category: Mielke T]]
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[[Category: Schulten, K.]]
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[[Category: Schulten K]]
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[[Category: Westhof, E.]]
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[[Category: Westhof E]]
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[[Category: Cotranslational protein translocation]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Isopeptide bond]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Protein conducting channel]]
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[[Category: Protein exit tunnel]]
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[[Category: Protein transport]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome]]
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[[Category: Rna-binding]]
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[[Category: Rrna-binding]]
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[[Category: Signal sequence]]
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[[Category: Translocation]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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Current revision

Cryo-EM structure of idle yeast Ssh1 complex bound to the yeast 80S ribosome

2wwa, resolution 8.90Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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