3ras

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[[Image:3ras.png|left|200px]]
 
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==Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) complexed with a lipophilic phosphonate inhibitor==
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The line below this paragraph, containing "STRUCTURE_3ras", creates the "Structure Box" on the page.
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<StructureSection load='3ras' size='340' side='right'caption='[[3ras]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ras]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RAS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCV:[(1R)-3-[ACETYL(HYDROXY)AMINO]-1-(3,4-DICHLOROPHENYL)PROPYL]PHOSPHONIC+ACID'>DCV</scene>, <scene name='pdbligand=FM5:3-(N-HYDROXYACETAMIDO)-1-(3,4-DICHLOROPHENYL)PROPYLPHOSPHONIC+ACID'>FM5</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ras| PDB=3ras | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ras FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ras OCA], [https://pdbe.org/3ras PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ras RCSB], [https://www.ebi.ac.uk/pdbsum/3ras PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ras ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DXR_MYCTU DXR_MYCTU] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
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===Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) complexed with a lipophilic phosphonate inhibitor===
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==See Also==
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*[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21561155 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21561155}}
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==About this Structure==
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[[3ras]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAS OCA].
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==Reference==
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<ref group="xtra">PMID:021561155</ref><references group="xtra"/>
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[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Deng, L.]]
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[[Category: Deng L]]
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[[Category: Diao, J.]]
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[[Category: Diao J]]
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[[Category: Prasad, B V.V.]]
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[[Category: Prasad BVV]]
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[[Category: Song, Y.]]
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[[Category: Song Y]]
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[[Category: 1-deoxy-d-xylulose 5-phosphate reductoisomerase]]
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[[Category: Doxp/mep pathway]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-inhibitor complex]]
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Current revision

Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) complexed with a lipophilic phosphonate inhibitor

PDB ID 3ras

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