3edu

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[[Image:3edu.png|left|200px]]
 
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==Crystal structure of the ankyrin-binding domain of human erythroid spectrin==
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The line below this paragraph, containing "STRUCTURE_3edu", creates the "Structure Box" on the page.
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<StructureSection load='3edu' size='340' side='right'caption='[[3edu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3edu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EDU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3edu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3edu OCA], [https://pdbe.org/3edu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3edu RCSB], [https://www.ebi.ac.uk/pdbsum/3edu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3edu ProSAT]</span></td></tr>
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{{STRUCTURE_3edu| PDB=3edu | SCENE= }}
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</table>
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== Disease ==
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===Crystal structure of the ankyrin-binding domain of human erythroid spectrin===
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[https://www.uniprot.org/uniprot/SPTB1_HUMAN SPTB1_HUMAN] Defects in SPTB are the cause of elliptocytosis type 3 (EL3) [MIM:[https://omim.org/entry/182870 182870]. EL3 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.<ref>PMID:8226774</ref> <ref>PMID:7883966</ref> <ref>PMID:8018926</ref> <ref>PMID:1975598</ref> Defects in SPTB are the cause of spherocytosis type 2 (SPH2) [MIM:[https://omim.org/entry/182870 182870]; also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant.
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== Function ==
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[https://www.uniprot.org/uniprot/SPTB1_HUMAN SPTB1_HUMAN] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
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== Evolutionary Conservation ==
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The line below this paragraph, {{ABSTRACT_PUBMED_19168783}}, adds the Publication Abstract to the page
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19168783 is the PubMed ID number.
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Check<jmol>
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<jmolCheckbox>
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{{ABSTRACT_PUBMED_19168783}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/3edu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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[[3edu]] is a 1 chain structure of [[Spectrin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDU OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3edu ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Spectrin]]
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*[[Spectrin 3D structures|Spectrin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019168783</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Morrow, J S.]]
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[[Category: Large Structures]]
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[[Category: Simonovic, I.]]
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[[Category: Morrow JS]]
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[[Category: Simonovic, M.]]
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[[Category: Simonovic I]]
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[[Category: Stabach, P.]]
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[[Category: Simonovic M]]
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[[Category: Steitz, T A.]]
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[[Category: Stabach P]]
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[[Category: Actin capping]]
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[[Category: Steitz TA]]
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[[Category: Actin-binding]]
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[[Category: Ankyrin]]
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[[Category: Ankyrin-binding domain]]
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[[Category: Cytoskeleton]]
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[[Category: Disease mutation]]
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[[Category: Elliptocytosis]]
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[[Category: Hereditary hemolytic anemia]]
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[[Category: Phosphoprotein]]
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[[Category: Spectrin]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of the ankyrin-binding domain of human erythroid spectrin

PDB ID 3edu

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