3qkj

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[[Image:3qkj.png|left|200px]]
 
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==The PWWP domain of human DNA (CYTOSINE-5-)-METHYLTRANSFERASE 3 BETA in complex with a bis-tris molecule==
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The line below this paragraph, containing "STRUCTURE_3qkj", creates the "Structure Box" on the page.
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<StructureSection load='3qkj' size='340' side='right'caption='[[3qkj]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qkj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QKJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3qkj| PDB=3qkj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qkj OCA], [https://pdbe.org/3qkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qkj RCSB], [https://www.ebi.ac.uk/pdbsum/3qkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qkj ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] ICF syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10647011</ref> <ref>PMID:10555141</ref> <ref>PMID:10588719</ref> <ref>PMID:11102980</ref> <ref>PMID:15580563</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.<ref>PMID:16357870</ref> <ref>PMID:17303076</ref> <ref>PMID:18413740</ref> <ref>PMID:18567530</ref>
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===The PWWP domain of human DNA (CYTOSINE-5-)-METHYLTRANSFERASE 3 BETA in complex with a bis-tris molecule===
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==See Also==
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21720545 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21720545}}
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==About this Structure==
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[[3qkj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QKJ OCA].
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==Reference==
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<ref group="xtra">PMID:021720545</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Amaya, M F.]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Amaya MF]]
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[[Category: Botchkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M.]]
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[[Category: Botchkarev A]]
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[[Category: Mackenzie, F.]]
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[[Category: Edwards AM]]
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[[Category: Min, J.]]
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[[Category: Mackenzie F]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Min J]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Zeng, H.]]
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[[Category: Zeng H]]
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[[Category: Dnmt3b]]
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[[Category: Methyltransferase 3 beta]]
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[[Category: Pwwp domain]]
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[[Category: S-adenosyl-l-methionine]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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[[Category: Zinc-finger]]
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Current revision

The PWWP domain of human DNA (CYTOSINE-5-)-METHYLTRANSFERASE 3 BETA in complex with a bis-tris molecule

PDB ID 3qkj

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