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3s9g

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'''Unreleased structure'''
 
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The entry 3s9g is ON HOLD until Paper Publication
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==Structure of human Hexim1 (delta stammer) coiled coil domain==
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<StructureSection load='3s9g' size='340' side='right'caption='[[3s9g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: Bigalke, J.M., Blankenfeldt, W., Geyer, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3s9g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S9G FirstGlance]. <br>
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Description: Structure of human Hexim1 (delta stammer) coiled coil domain
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s9g OCA], [https://pdbe.org/3s9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s9g RCSB], [https://www.ebi.ac.uk/pdbsum/3s9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s9g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEXI1_HUMAN HEXI1_HUMAN] Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.<ref>PMID:12941847</ref> <ref>PMID:12581153</ref> <ref>PMID:14580347</ref> <ref>PMID:12832472</ref> <ref>PMID:15201869</ref> <ref>PMID:15713661</ref> <ref>PMID:15940264</ref> <ref>PMID:15941832</ref> <ref>PMID:17088550</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bigalke JM]]
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[[Category: Blankenfeldt W]]
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[[Category: Geyer M]]

Current revision

Structure of human Hexim1 (delta stammer) coiled coil domain

PDB ID 3s9g

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