3ztl
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3ztl is ON HOLD until Paper Publication Authors: Saccoccia, F., Angelucci, F., Bellelli, A., Boumis, G., Brunori, M., Miele, A.E. Description: Crys...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of decameric form of Peroxiredoxin I from Schistosoma mansoni== | |
| + | <StructureSection load='3ztl' size='340' side='right'caption='[[3ztl]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ztl]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZTL FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ztl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztl OCA], [https://pdbe.org/3ztl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ztl RCSB], [https://www.ebi.ac.uk/pdbsum/3ztl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ztl ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/O97161_SCHMA O97161_SCHMA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | 2-Cys peroxiredoxins (Prxs) play two different roles depending on the physiological status of the cell. They are thioredoxin-dependent peroxidases under low oxidative stress and ATP-independent chaperones upon exposure to high peroxide concentrations. These alternative functions have been associated with changes in the oligomerization state from low-(LMW) to high-molecular-weight (HMW) species. Here we present the structures of Schistosoma mansoni PrxI in both states: the LMW decamer and the HMW 20-mer formed by two stacked decamers. The latter is the structure of a 2-Cys Prx chaperonic form. Comparison of the structures sheds light on the mechanism by which chemical stressors, such as high H(2)O(2) concentration and acidic pH, are sensed and translated into a functional switch in this protein family. We also propose a model to account for the in vivo formation of long filaments of stacked Prx rings. | ||
| - | + | Moonlighting by different stressors: crystal structure of the chaperone species of a 2-cys peroxiredoxin.,Saccoccia F, Di Micco P, Boumis G, Brunori M, Koutris I, Miele AE, Morea V, Sriratana P, Williams DL, Bellelli A, Angelucci F Structure. 2012 Mar 7;20(3):429-39. PMID:22405002<ref>PMID:22405002</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3ztl" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Schistosoma mansoni]] | ||
| + | [[Category: Angelucci F]] | ||
| + | [[Category: Bellelli A]] | ||
| + | [[Category: Boumis G]] | ||
| + | [[Category: Brunori M]] | ||
| + | [[Category: Miele AE]] | ||
| + | [[Category: Saccoccia F]] | ||
Current revision
Crystal structure of decameric form of Peroxiredoxin I from Schistosoma mansoni
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