3q5u

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[[Image:3q5u.png|left|200px]]
 
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==A minimal NLS from human scramblase 4 complexed with importin alpha==
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The line below this paragraph, containing "STRUCTURE_3q5u", creates the "Structure Box" on the page.
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<StructureSection load='3q5u' size='340' side='right'caption='[[3q5u]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q5U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q5u OCA], [https://pdbe.org/3q5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q5u RCSB], [https://www.ebi.ac.uk/pdbsum/3q5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q5u ProSAT]</span></td></tr>
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{{STRUCTURE_3q5u| PDB=3q5u | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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===A minimal NLS from human scramblase 4 complexed with importin alpha===
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==See Also==
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*[[Importin 3D structures|Importin 3D structures]]
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__TOC__
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_21690087}}
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==About this Structure==
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[[3q5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q5U OCA].
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==Reference==
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<ref group="xtra">PMID:021690087</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bhardwaj, A.]]
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[[Category: Bhardwaj A]]
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[[Category: Cingolani, G.]]
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[[Category: Cingolani G]]
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[[Category: Armadillo repeat]]
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[[Category: Protein transport]]
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[[Category: Protein transport-membrane protein complex]]
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Current revision

A minimal NLS from human scramblase 4 complexed with importin alpha

PDB ID 3q5u

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