This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3qlr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:49, 14 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3qlr.jpg|left|200px]]
 
-
<!--
+
==Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)==
-
The line below this paragraph, containing "STRUCTURE_3qlr", creates the "Structure Box" on the page.
+
<StructureSection load='3qlr' size='340' side='right'caption='[[3qlr]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3qlr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QLR FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.149&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=QLR:6-METHYL-5-[(3R)-3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE'>QLR</scene></td></tr>
-
{{STRUCTURE_3qlr| PDB=3qlr | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qlr OCA], [https://pdbe.org/3qlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qlr RCSB], [https://www.ebi.ac.uk/pdbsum/3qlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qlr ProSAT]</span></td></tr>
-
 
+
</table>
-
===Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/DYR_CANAX DYR_CANAX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21726415}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 21726415 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_21726415}}
+
-
 
+
-
==About this Structure==
+
-
[[3qlr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLR OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021726415</ref><references group="xtra"/>
+
[[Category: Candida albicans]]
[[Category: Candida albicans]]
-
[[Category: Anderson, A C.]]
+
[[Category: Large Structures]]
-
[[Category: Bendel, S D.]]
+
[[Category: Anderson AC]]
-
[[Category: Paulsen, J L.]]
+
[[Category: Bendel SD]]
-
[[Category: Antifungal agent]]
+
[[Category: Paulsen JL]]
-
[[Category: Candida albican]]
+
-
[[Category: Drug design]]
+
-
[[Category: Enzyme inhibitor]]
+
-
[[Category: Fungal protein]]
+
-
[[Category: Model]]
+
-
[[Category: Molecular structure]]
+
-
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+
-
[[Category: Structure-activity relationship]]
+
-
[[Category: Tetrahydrofolate dehydrogenase]]
+

Current revision

Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)

PDB ID 3qlr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3qlr"
Personal tools