3skd

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[[Image:3skd.jpg|left|200px]]
 
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==Crystal structure of the Thermus thermophilus cas3 HD domain in the presence of Ni2+==
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The line below this paragraph, containing "STRUCTURE_3skd", creates the "Structure Box" on the page.
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<StructureSection load='3skd' size='340' side='right'caption='[[3skd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3skd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SKD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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{{STRUCTURE_3skd| PDB=3skd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3skd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3skd OCA], [https://pdbe.org/3skd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3skd RCSB], [https://www.ebi.ac.uk/pdbsum/3skd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3skd ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the Thermus thermophilus cas3 HD domain in the presence of Ni2+===
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== Function ==
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[https://www.uniprot.org/uniprot/CAS3_THET8 CAS3_THET8] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity. The N-terminal domain (residues 6-260) acts as a ssDNA endonuclease, has no activity on dsDNA.<ref>PMID:21775431</ref>
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== References ==
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==About this Structure==
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<references/>
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[[3skd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKD OCA].
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__TOC__
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[[Category: Thermus thermophilus hb8]]
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</StructureSection>
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[[Category: Bailey, S.]]
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[[Category: Large Structures]]
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[[Category: Mulepati, S.]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Ca]]
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[[Category: Bailey S]]
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[[Category: Crispr]]
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[[Category: Mulepati S]]
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[[Category: Hd domain]]
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[[Category: Hydrolase]]
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[[Category: Nuclease]]
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Current revision

Crystal structure of the Thermus thermophilus cas3 HD domain in the presence of Ni2+

PDB ID 3skd

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