2iay

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(New page: 200px<br /><applet load="2iay" size="350" color="white" frame="true" align="right" spinBox="true" caption="2iay, resolution 1.200&Aring;" /> '''Crystal structure o...)
Current revision (09:11, 6 November 2024) (edit) (undo)
 
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[[Image:2iay.gif|left|200px]]<br /><applet load="2iay" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2iay, resolution 1.200&Aring;" />
 
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'''Crystal structure of a protein with unknown function from Lactobacillus plantarum at 1.20 A resolution'''<br />
 
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==About this Structure==
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==Crystal structure of a duf1831 family protein (lp2179) from lactobacillus plantarum at 1.20 A resolution==
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2IAY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_plantarum Lactobacillus plantarum] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAY OCA].
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<StructureSection load='2iay' size='340' side='right'caption='[[2iay]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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[[Category: Lactobacillus plantarum]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2iay]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum Lactiplantibacillus plantarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IAY FirstGlance]. <br>
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[[Category: JCSG, Joint.Center.for.Structural.Genomics.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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[[Category: CL]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: GOL]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iay OCA], [https://pdbe.org/2iay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iay RCSB], [https://www.ebi.ac.uk/pdbsum/2iay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iay ProSAT], [https://www.topsan.org/Proteins/JCSG/2iay TOPSAN]</span></td></tr>
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[[Category: hypothetical protein]]
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</table>
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[[Category: jcsg]]
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== Function ==
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[[Category: joint center for structural genomics]]
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[https://www.uniprot.org/uniprot/F9UQB2_LACPL F9UQB2_LACPL]
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[[Category: np_785678.1]]
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== Evolutionary Conservation ==
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[[Category: protein structure initiative]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: psi-2]]
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Check<jmol>
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[[Category: structural genomics]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/2iay_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iay ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel alpha+beta fold comprising two beta-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokaryotic S-adenosylmethionine decarboxylases, is consistent with a role in amino-acid metabolism. Genomic neighborhood analysis of LP2179 supports this functional assignment, which might also then be extended to PF08868 and PF08968.
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 20:37:59 2008''
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Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism.,Bakolitsa C, Kumar A, Carlton D, Miller MD, Krishna SS, Abdubek P, Astakhova T, Axelrod HL, Chiu HJ, Clayton T, Deller MC, Duan L, Elsliger MA, Feuerhelm J, Grzechnik SK, Grant JC, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Marciano D, McMullan D, Morse AT, Nigoghossian E, Okach L, Oommachen S, Paulsen J, Reyes R, Rife CL, Tien HJ, Trout CV, van den Bedem H, Weekes D, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt, 10):1205-10. Epub 2009 Oct 27. PMID:20944212<ref>PMID:20944212</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2iay" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Lactiplantibacillus plantarum]]
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[[Category: Large Structures]]

Current revision

Crystal structure of a duf1831 family protein (lp2179) from lactobacillus plantarum at 1.20 A resolution

PDB ID 2iay

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