2yin

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[[Image:2yin.png|left|200px]]
 
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==STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.==
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The line below this paragraph, containing "STRUCTURE_2yin", creates the "Structure Box" on the page.
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<StructureSection load='2yin' size='340' side='right'caption='[[2yin]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yin]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YIN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yin OCA], [https://pdbe.org/2yin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yin RCSB], [https://www.ebi.ac.uk/pdbsum/2yin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yin ProSAT]</span></td></tr>
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{{STRUCTURE_2yin| PDB=2yin | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOCK2_HUMAN DOCK2_HUMAN] Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.<ref>PMID:21613211</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DOCK (dedicator of cytokinesis) guanine nucleotide exchange factors (GEFs) activate the Rho-family GTPases Rac and Cdc42 to control cell migration, morphogenesis, and phagocytosis. The DOCK A and B subfamilies activate Rac, whereas the DOCK D subfamily activates Cdc42. Nucleotide exchange is catalyzed by a conserved DHR2 domain (DOCK(DHR2)). Although the molecular basis for DOCK(DHR2)-mediated GTPase activation has been elucidated through structures of a DOCK9(DHR2)-Cdc42 complex, the factors determining recognition of specific GTPases are unknown. To understand the molecular basis for DOCK-GTPase specificity, we have determined the crystal structure of DOCK2(DHR2) in complex with Rac1. DOCK2(DHR2) and DOCK9(DHR2) exhibit similar tertiary structures and homodimer interfaces and share a conserved GTPase-activating mechanism. Multiple structural differences between DOCK2(DHR2) and DOCK9(DHR2) account for their selectivity toward Rac1 and Cdc42. Key determinants of selectivity of Cdc42 and Rac for their cognate DOCK(DHR2) are a Phe or Trp residue within beta3 (residue 56) and the ability of DOCK proteins to exploit differences in the GEF-induced conformational changes of switch 1 dependent on a divergent residue at position 27. DOCK proteins, therefore, differ from DH-PH GEFs that select their cognate GTPases through recognition of structural differences within the beta2/beta3 strands.
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===STRUCTURE OF THE COMPLEX BETWEEN DOCK2 AND RAC1.===
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Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors.,Kulkarni K, Yang J, Zhang Z, Barford D J Biol Chem. 2011 Jul 15;286(28):25341-51. Epub 2011 May 24. PMID:21613211<ref>PMID:21613211</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2yin" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21613211}}, adds the Publication Abstract to the page
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*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21613211 is the PubMed ID number.
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*[[Rac 3D structures|Rac 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_21613211}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[2yin]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIN OCA].
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==Reference==
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<ref group="xtra">PMID:021613211</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barford, D.]]
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[[Category: Large Structures]]
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[[Category: Kulkarni, K A.]]
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[[Category: Barford D]]
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[[Category: Yang, J.]]
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[[Category: Kulkarni KA]]
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[[Category: Zhang, Z.]]
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[[Category: Yang J]]
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[[Category: Apoptosis]]
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[[Category: Zhang Z]]
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[[Category: Dock]]
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[[Category: Dock guanine nucleotide exchange factor]]
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[[Category: Rho gtpase]]
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Current revision

STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.

PDB ID 2yin

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